Gene description for AKR1C3
Gene name aldo-keto reductase family 1, member C3
Gene symbol AKR1C3
Other names/aliases DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
Species Homo sapiens
 Database cross references - AKR1C3
ExoCarta ExoCarta_8644
Entrez Gene 8644
HGNC 386
MIM 603966
UniProt P42330  
 AKR1C3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for AKR1C3
Molecular Function
    retinal dehydrogenase activity GO:0001758 IDA
    geranylgeranyl reductase activity GO:0045550 IDA
    androsterone dehydrogenase activity GO:0047023 IDA
    phenanthrene 9,10-monooxygenase activity GO:0018636 IDA
    15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity GO:0047020 IDA
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity GO:0047115 IEA
    alditol:NADP+ 1-oxidoreductase activity GO:0004032 IDA
    ketosteroid monooxygenase activity GO:0047086 IDA
    testosterone 17-beta-dehydrogenase (NADP+) activity GO:0047045 IEA
    ketoreductase activity GO:0045703 IDA
    retinol dehydrogenase activity GO:0004745 IDA
    indanol dehydrogenase activity GO:0047718 IEA
    delta4-3-oxosteroid 5beta-reductase activity GO:0047787 IDA
    aldo-keto reductase (NADP) activity GO:0004033 TAS
    prostaglandin D2 11-ketoreductase activity GO:0036131 IEA
    prostaglandin-F synthase activity GO:0047017 IEA
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016655 IDA
    dihydrotestosterone 17-beta-dehydrogenase activity GO:0035410 IDA
    testosterone dehydrogenase (NAD+) activity GO:0047035 IEA
Biological Process
    farnesol catabolic process GO:0016488 IDA
    positive regulation of protein kinase B signaling GO:0051897 IDA
    positive regulation of cell proliferation GO:0008284 IMP
    progesterone metabolic process GO:0042448 IDA
    prostaglandin metabolic process GO:0006693 TAS
    renal absorption GO:0070293 NAS
    arachidonic acid metabolic process GO:0019369 TAS
    cellular response to corticosteroid stimulus GO:0071384 IDA
    cellular response to jasmonic acid stimulus GO:0071395 IDA
    male gonad development GO:0008584 IEP
    cellular response to prostaglandin D stimulus GO:0071799 IDA
    oxidation-reduction process GO:0055114 TAS
    cellular response to calcium ion GO:0071277 IDA
    cyclooxygenase pathway GO:0019371 TAS
    positive regulation of reactive oxygen species metabolic process GO:2000379 IDA
    cellular response to cadmium ion GO:0071276 IDA
    negative regulation of retinoic acid biosynthetic process GO:1900053 IDA
    phototransduction, visible light GO:0007603 TAS
    steroid metabolic process GO:0008202 IEP
    G-protein coupled receptor signaling pathway GO:0007186 IDA
    doxorubicin metabolic process GO:0044598 IMP
    protein import into nucleus, translocation GO:0000060 IDA
    response to nutrient GO:0007584 IEP
    cellular response to reactive oxygen species GO:0034614 IDA
    positive regulation of endothelial cell apoptotic process GO:2000353 IDA
    keratinocyte differentiation GO:0030216 IEP
    cellular response to prostaglandin stimulus GO:0071379 IDA
    daunorubicin metabolic process GO:0044597 IMP
    retinoid metabolic process GO:0001523 TAS
    positive regulation of cell death GO:0010942 IDA
    regulation of retinoic acid receptor signaling pathway GO:0048385 IDA
    retinal metabolic process GO:0042574 IDA
    regulation of testosterone biosynthetic process GO:2000224 IMP
    multicellular organismal macromolecule metabolic process GO:0044259 IEP
    cellular response to starvation GO:0009267 IEP
    testosterone biosynthetic process GO:0061370 IMP
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    intracellular GO:0005622 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified AKR1C3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AKR1C3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLJ11011  
Two-hybrid Homo sapiens
2 ZHX1  
Two-hybrid Homo sapiens
3 MAGEA11  
Two-hybrid Homo sapiens
4 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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