Gene description for PGLYRP3
Gene name peptidoglycan recognition protein 3
Gene symbol PGLYRP3
Other names/aliases PGLYRPIalpha
PGRP-Ialpha
PGRPIA
Species Homo sapiens
 Database cross references - PGLYRP3
ExoCarta ExoCarta_114771
Entrez Gene 114771
HGNC 30014
MIM 608197
UniProt Q96LB9  
 PGLYRP3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PGLYRP3
Molecular Function
    peptidoglycan binding GO:0042834 IDA
    peptidoglycan receptor activity GO:0016019 IDA
    N-acetylmuramoyl-L-alanine amidase activity GO:0008745 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    defense response to Gram-positive bacterium GO:0050830 IDA
    detection of bacterium GO:0016045 IDA
    negative regulation of natural killer cell differentiation involved in immune response GO:0032827 IEA
    peptidoglycan catabolic process GO:0009253 IEA
    negative regulation of interferon-gamma production GO:0032689 IEA
    growth of symbiont in host GO:0044117 IEA
    pattern recognition receptor signaling pathway GO:0002221 IDA
    innate immune response GO:0045087 NAS
Subcellular Localization
    extracellular region GO:0005576 IEA
    intracellular GO:0005622 NAS
    membrane GO:0016020 NAS
 Experiment description of studies that identified PGLYRP3 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PGLYRP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PGLYRP3 is involved
No pathways found





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