Gene description for PRSS48
Gene name protease, serine, 48
Gene symbol PRSS48
Other names/aliases ESSPL
Species Homo sapiens
 Database cross references - PRSS48
ExoCarta ExoCarta_345062
Vesiclepedia VP_345062
Entrez Gene 345062
HGNC 24635
UniProt Q7RTY5  
 PRSS48 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PRSS48
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    protein binding GO:0005515 IPI
Biological Process
    proteolysis GO:0006508 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified PRSS48 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PRSS48
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM68 55128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 A4GNT  
Affinity Capture-MS Homo sapiens
3 PDF  
Affinity Capture-MS Homo sapiens
4 UBXN2B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRSS48 is involved
No pathways found





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