Gene description for RTN4R
Gene name reticulon 4 receptor
Gene symbol RTN4R
Other names/aliases NGR
NOGOR
Species Homo sapiens
 Database cross references - RTN4R
ExoCarta ExoCarta_65078
Entrez Gene 65078
HGNC 18601
MIM 605566
UniProt Q9BZR6  
 RTN4R identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RTN4R
Molecular Function
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 NAS
Biological Process
    regulation of axonogenesis GO:0050770 TAS
    negative regulation of axonogenesis GO:0050771 TAS
    axonogenesis GO:0007409 NAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
Subcellular Localization
    anchored component of membrane GO:0031225 IEA
    cell surface GO:0009986 IDA
    plasma membrane GO:0005886 TAS
    growth cone GO:0030426 IEA
    endoplasmic reticulum GO:0005783 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified RTN4R in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for RTN4R
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RTN4R is involved
PathwayEvidenceSource
Axonal growth inhibition (RHOA activation) TAS Reactome





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