Gene description for PANK2
Gene name pantothenate kinase 2
Gene symbol PANK2
Other names/aliases C20orf48
HARP
HSS
NBIA1
PKAN
Species Homo sapiens
 Database cross references - PANK2
ExoCarta ExoCarta_80025
Vesiclepedia VP_80025
Entrez Gene 80025
HGNC 15894
MIM 606157
UniProt Q9BZ23  
 PANK2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for PANK2
Molecular Function
    pantothenate kinase activity GO:0004594 IEA
    ATP binding GO:0005524 IEA
Biological Process
    coenzyme A biosynthetic process GO:0015937 IEA
    mitochondrion morphogenesis GO:0070584 IEA
    coenzyme biosynthetic process GO:0009108 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    regulation of mitochondrial membrane potential GO:0051881 IEA
    vitamin metabolic process GO:0006766 TAS
    spermatid development GO:0007286 IEA
    pantothenate metabolic process GO:0015939 TAS
    aerobic respiration GO:0009060 IEA
    small molecule metabolic process GO:0044281 TAS
    phosphorylation GO:0016310 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    mitochondrial intermembrane space GO:0005758 TAS
 Experiment description of studies that identified PANK2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 224
MISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101|CD63|CD81
EV Enriched markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PANK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAQ 10971
Affinity Capture-MS Homo sapiens
2 RASGRF2  
Affinity Capture-MS Homo sapiens
3 VDAC1 7416
Affinity Capture-MS Homo sapiens
4 DKFZP434P0316  
Affinity Capture-MS Homo sapiens
5 DHX36 170506
Affinity Capture-MS Homo sapiens
6 LXN 56925
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PANK2 is involved
PathwayEvidenceSource
Coenzyme A biosynthesis TAS Reactome





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