Gene description for PANK3
Gene name pantothenate kinase 3
Gene symbol PANK3
Other names/aliases -
Species Homo sapiens
 Database cross references - PANK3
ExoCarta ExoCarta_79646
Vesiclepedia VP_79646
Entrez Gene 79646
HGNC 19365
MIM 606161
UniProt Q9H999  
 PANK3 identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for PANK3
Molecular Function
    pantothenate kinase activity GO:0004594 IBA
    pantothenate kinase activity GO:0004594 IDA
    pantothenate kinase activity GO:0004594 IMP
    ATP binding GO:0005524 IDA
    vitamin binding GO:0019842 IDA
    protein homodimerization activity GO:0042803 IDA
    acetyl-CoA binding GO:1905502 IDA
Biological Process
    coenzyme A biosynthetic process GO:0015937 IBA
    coenzyme A biosynthetic process GO:0015937 IDA
    coenzyme A biosynthetic process GO:0015937 IEA
    coenzyme A biosynthetic process GO:0015937 IMP
    phosphorylation GO:0016310 IDA
    phosphorylation GO:0016310 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified PANK3 in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for PANK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCD 6319
Affinity Capture-MS Homo sapiens
2 FADS2 9415
Affinity Capture-MS Homo sapiens
3 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
4 PANK2 80025
Affinity Capture-MS Homo sapiens
5 PARK2  
Affinity Capture-MS Homo sapiens
6 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml



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