Gene description for SAT2
Gene name spermidine/spermine N1-acetyltransferase family member 2
Gene symbol SAT2
Other names/aliases SSAT2
Species Homo sapiens
 Database cross references - SAT2
ExoCarta ExoCarta_112483
Entrez Gene 112483
HGNC 23160
MIM 611463
UniProt Q96F10  
 SAT2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 19056867    
 Gene ontology annotations for SAT2
Molecular Function
    diamine N-acetyltransferase activity GO:0004145 IDA
Biological Process
    spermidine acetylation GO:0032918 IDA
    putrescine catabolic process GO:0009447 IEA
    nor-spermidine metabolic process GO:0046204 IDA
    putrescine acetylation GO:0032920 IDA
    spermine acetylation GO:0032919 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SAT2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SAT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAT  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SAT2 is involved
No pathways found





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