Gene description for SLIT1
Gene name slit homolog 1 (Drosophila)
Gene symbol SLIT1
Other names/aliases MEGF4
SLIL1
SLIT-1
SLIT3
Species Homo sapiens
 Database cross references - SLIT1
ExoCarta ExoCarta_6585
Vesiclepedia VP_6585
Entrez Gene 6585
HGNC 11085
MIM 603742
UniProt O75093  
 SLIT1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLIT1
Molecular Function
    calcium ion binding GO:0005509 NAS
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IBA
    heparan sulfate proteoglycan binding GO:0043395 IEA
    Roundabout binding GO:0048495 IBA
    Roundabout binding GO:0048495 IPI
Biological Process
    nuclear migration GO:0007097 IEA
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 IDA
    motor neuron axon guidance GO:0008045 IMP
    spinal cord development GO:0021510 IEA
    chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration GO:0021834 IDA
    retinal ganglion cell axon guidance GO:0031290 IEA
    dorsal/ventral axon guidance GO:0033563 IEA
    negative regulation of axon extension involved in axon guidance GO:0048843 IEA
    axon extension involved in axon guidance GO:0048846 IDA
    forebrain morphogenesis GO:0048853 NAS
    negative chemotaxis GO:0050919 IBA
    negative chemotaxis GO:0050919 IDA
    negative regulation of synapse assembly GO:0051964 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 NAS
 Experiment description of studies that identified SLIT1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLIT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM42  
Two-hybrid Homo sapiens
2 ADAMTSL4  
Two-hybrid Homo sapiens
3 MEOX2  
Two-hybrid Homo sapiens
4 KRTAP10-8  
Two-hybrid Homo sapiens
5 KRTAP13-3  
Two-hybrid Homo sapiens
6 FHL5 9457
Two-hybrid Homo sapiens
7 ZNF620  
Two-hybrid Homo sapiens
8 CUL3 8452
Affinity Capture-MS Homo sapiens
9 MKRN2 23609
Affinity Capture-RNA Homo sapiens
10 MTNR1A  
Two-hybrid Homo sapiens
11 KRTAP1-1  
Two-hybrid Homo sapiens
12 CYSRT1 375791
Two-hybrid Homo sapiens
13 HOXA1 3198
Two-hybrid Homo sapiens
14 ATN1  
Two-hybrid Homo sapiens
15 KRTAP13-2  
Two-hybrid Homo sapiens
View the network image/svg+xml



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