Gene description for CDH4
Gene name cadherin 4, type 1, R-cadherin (retinal)
Gene symbol CDH4
Other names/aliases CAD4
R-CAD
RCAD
Species Homo sapiens
 Database cross references - CDH4
ExoCarta ExoCarta_1002
Vesiclepedia VP_1002
Entrez Gene 1002
HGNC 1763
MIM 603006
UniProt P55283  
 CDH4 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CDH4
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell-cell junction organization GO:0045216 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    axon guidance GO:0007411 IEA
    cell adhesion GO:0007155 TAS
    cell junction assembly GO:0034329 TAS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IEA
    adherens junction organization GO:0034332 TAS
    positive regulation of axon extension GO:0045773 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IEA
 Experiment description of studies that identified CDH4 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CDH4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH2 1000
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which CDH4 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome
CDO in myogenesis TAS Reactome





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