Gene description for SPINK5
Gene name serine peptidase inhibitor, Kazal type 5
Gene symbol SPINK5
Other names/aliases LEKTI
LETKI
NETS
NS
VAKTI
Species Homo sapiens
 Database cross references - SPINK5
ExoCarta ExoCarta_11005
Entrez Gene 11005
HGNC 15464
MIM 605010
UniProt Q9NQ38  
 SPINK5 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for SPINK5
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IDA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IEA
    anagen GO:0042640 TAS
    regulation of T cell differentiation GO:0045580 TAS
    extracellular matrix organization GO:0030198 TAS
    epidermal cell differentiation GO:0009913 IDA
    negative regulation of angiogenesis GO:0016525 TAS
    epithelial cell differentiation GO:0030855 TAS
    negative regulation of serine-type peptidase activity GO:1902572 IEA
    hair cell differentiation GO:0035315 TAS
    negative regulation of immune response GO:0050777 TAS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    cell cortex GO:0005938 IDA
    endoplasmic reticulum GO:0005783 IDA
    epidermal lamellar body GO:0097209 IDA
    cytosol GO:0005829 IDA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 NAS
 Experiment description of studies that identified SPINK5 in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SPINK5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SPINK5 is involved
No pathways found





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