Gene description for MEGF10
Gene name multiple EGF-like-domains 10
Gene symbol MEGF10
Other names/aliases EMARDD
Species Homo sapiens
 Database cross references - MEGF10
ExoCarta ExoCarta_84466
Entrez Gene 84466
HGNC 29634
MIM 612453
UniProt Q96KG7  
 MEGF10 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for MEGF10
Biological Process
    muscle cell development GO:0055001 IMP
    regulation of skeletal muscle tissue development GO:0048641 IMP
    homotypic cell-cell adhesion GO:0034109 IDA
    skeletal muscle satellite cell differentiation GO:0014816 IMP
    recognition of apoptotic cell GO:0043654 IEA
    regulation of muscle cell differentiation GO:0051147 IMP
    skeletal muscle satellite cell proliferation GO:0014841 ISS
    skeletal muscle satellite cell activation GO:0014719 ISS
Subcellular Localization
    phagocytic cup GO:0001891 IEA
    integral component of membrane GO:0016021 IEA
    basolateral plasma membrane GO:0016323 IEA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified MEGF10 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for MEGF10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MEGF10 is involved
No pathways found





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