Gene description for MEGF10
Gene name multiple EGF-like-domains 10
Gene symbol MEGF10
Other names/aliases EMARDD
Species Homo sapiens
 Database cross references - MEGF10
ExoCarta ExoCarta_84466
Vesiclepedia VP_84466
Entrez Gene 84466
HGNC 29634
MIM 612453
UniProt Q96KG7  
 MEGF10 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for MEGF10
Molecular Function
    complement component C1q complex binding GO:0001849 IDA
    scavenger receptor activity GO:0005044 IDA
    Notch binding GO:0005112 IBA
    Notch binding GO:0005112 IPI
Biological Process
    skeletal muscle satellite cell activation GO:0014719 ISS
    skeletal muscle satellite cell differentiation GO:0014816 IMP
    skeletal muscle satellite cell proliferation GO:0014841 ISS
    positive regulation of cell-cell adhesion GO:0022409 IMP
    muscle cell proliferation GO:0033002 IMP
    homotypic cell-cell adhesion GO:0034109 IDA
    apoptotic cell clearance GO:0043277 IBA
    engulfment of apoptotic cell GO:0043652 ISS
    recognition of apoptotic cell GO:0043654 IEA
    myoblast development GO:0048627 IEA
    regulation of skeletal muscle tissue development GO:0048641 IMP
    regulation of muscle cell differentiation GO:0051147 IMP
    myoblast migration GO:0051451 IMP
    muscle cell development GO:0055001 IMP
    apoptotic process involved in development GO:1902742 ISS
    positive regulation of myoblast proliferation GO:2000288 IMP
Subcellular Localization
    phagocytic cup GO:0001891 IDA
    plasma membrane GO:0005886 IDA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified MEGF10 in sEVs
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for MEGF10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP2M1 1173
Two-hybrid Homo sapiens
2 SNRNP200 23020
Two-hybrid Homo sapiens
3 SYK 6850
Affinity Capture-Western Homo sapiens
4 DHX16 8449
Two-hybrid Homo sapiens
5 GRB10 2887
Two-hybrid Homo sapiens
6 RANBP10 57610
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MEGF10 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here