Gene description for SGK3
Gene name serum/glucocorticoid regulated kinase family, member 3
Gene symbol SGK3
Other names/aliases CISK
SGK2
SGKL
Species Homo sapiens
 Database cross references - SGK3
ExoCarta ExoCarta_23678
Vesiclepedia VP_23678
Entrez Gene 23678
HGNC 10812
MIM 607591
UniProt Q96BR1  
 SGK3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SGK3
Molecular Function
    potassium channel regulator activity GO:0015459 TAS
    calcium channel regulator activity GO:0005246 TAS
    protein binding GO:0005515 IPI
    sodium channel regulator activity GO:0017080 TAS
    protein kinase activity GO:0004672 TAS
    ATP binding GO:0005524 IEA
    phosphatidylinositol binding GO:0035091 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    chloride channel regulator activity GO:0017081 TAS
Biological Process
    response to stress GO:0006950 TAS
    regulation of cell migration GO:0030334 TAS
    regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS
    ion transmembrane transport GO:0034220 TAS
    transmembrane transport GO:0055085 TAS
    regulation of cell growth GO:0001558 TAS
    regulation of cell proliferation GO:0042127 TAS
    protein phosphorylation GO:0006468 IEA
Subcellular Localization
    early endosome GO:0005769 IEA
    recycling endosome GO:0055037 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SGK3 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SGK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC9A3R2 9351
Invitro Homo sapiens
2 GSK3B 2932
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SGK3 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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