Gene description for CTNNBIP1
Gene name catenin, beta interacting protein 1
Gene symbol CTNNBIP1
Other names/aliases ICAT
Species Homo sapiens
 Database cross references - CTNNBIP1
ExoCarta ExoCarta_56998
Vesiclepedia VP_56998
Entrez Gene 56998
HGNC 16913
MIM 607758
UniProt Q9NSA3  
 CTNNBIP1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CTNNBIP1
Molecular Function
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IBA
    beta-catenin binding GO:0008013 IPI
    armadillo repeat domain binding GO:0070016 IPI
Biological Process
    branching involved in ureteric bud morphogenesis GO:0001658 IEA
    regulation of vascular permeability involved in acute inflammatory response GO:0002528 IMP
    anterior/posterior pattern specification GO:0009952 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of Wnt signaling pathway GO:0030178 IBA
    negative regulation of protein-containing complex assembly GO:0031333 IEA
    negative regulation of protein binding GO:0032091 IDA
    negative regulation of DNA-binding transcription factor activity GO:0043433 IMP
    positive regulation of monocyte differentiation GO:0045657 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    negative regulation of smooth muscle cell proliferation GO:0048662 IEA
    negative regulation of transcription initiation by RNA polymerase II GO:0060633 IEA
    negative regulation of mesenchymal cell proliferation GO:0072201 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    beta-catenin destruction complex GO:0030877 IBA
    beta-catenin destruction complex GO:0030877 IDA
    beta-catenin-ICAT complex GO:1990711 IEA
 Experiment description of studies that identified CTNNBIP1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CTNNBIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 CASP4  
Affinity Capture-MS Homo sapiens
3 Ctnnb1 12387
Co-crystal Structure Mus musculus
4 CTNNA2 1496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CTNNA1 1495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GOT2 2806
Affinity Capture-MS Homo sapiens
7 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
8 KRTAP1-3  
Two-hybrid Homo sapiens
9 JUP 3728
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MSS51  
Two-hybrid Homo sapiens
11 RUVBL2 10856
Affinity Capture-Western Homo sapiens
12 NOTCH2NL 388677
Two-hybrid Homo sapiens
13 REL 5966
Two-hybrid Homo sapiens
14 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 INCA1  
Two-hybrid Homo sapiens
16 NBPF19  
Two-hybrid Homo sapiens
17 SPATA24  
Two-hybrid Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 KRTAP5-9  
Two-hybrid Homo sapiens
20 KRTAP10-3  
Two-hybrid Homo sapiens
21 BPGM 669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CTSA 5476
Affinity Capture-MS Homo sapiens
23 CPVL 54504
Affinity Capture-MS Homo sapiens
24 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
25 RPA3 6119
Affinity Capture-MS Homo sapiens
26 TK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GLB1 2720
Affinity Capture-MS Homo sapiens
28 PNMA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ATE1 11101
Affinity Capture-MS Homo sapiens
30 SSUH2  
Affinity Capture-MS Homo sapiens
31 USHBP1  
Two-hybrid Homo sapiens
32 BEND5  
Two-hybrid Homo sapiens
33 P4HA3 283208
Two-hybrid Homo sapiens
34 CTNNA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 APC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 STX17 55014
Affinity Capture-MS Homo sapiens
37 NACAP1  
Affinity Capture-MS Homo sapiens
38 GINS4  
Two-hybrid Homo sapiens
39 SGK3 23678
Affinity Capture-MS Homo sapiens
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