Gene description for AKAP10
Gene name A kinase (PRKA) anchor protein 10
Gene symbol AKAP10
Other names/aliases AKAP-10
D-AKAP-2
D-AKAP2
PRKA10
Species Homo sapiens
 Database cross references - AKAP10
ExoCarta ExoCarta_11216
Vesiclepedia VP_11216
Entrez Gene 11216
HGNC 368
MIM 604694
UniProt O43572  
 AKAP10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for AKAP10
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase A binding GO:0051018 IPI
Biological Process
    signal transduction GO:0007165 TAS
    protein localization GO:0008104 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified AKAP10 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AKAP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX27 81609
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 NPAS1  
Affinity Capture-MS Homo sapiens
4 LAMTOR1 55004
Proximity Label-MS Homo sapiens
5 LAMP3  
Proximity Label-MS Homo sapiens
6 S100A6 6277
Affinity Capture-MS Homo sapiens
7 RAB11A 8766
Proximity Label-MS Homo sapiens
8 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
9 PRKAR1A 5573
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
10 OVGP1  
Affinity Capture-MS Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 METTL21B  
Affinity Capture-MS Homo sapiens
13 DDX58 23586
Affinity Capture-RNA Homo sapiens
14 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
15 RAB4A 5867
Proximity Label-MS Homo sapiens
16 RPA3 6119
Proximity Label-MS Homo sapiens
17 MYH9 4627
Co-fractionation Homo sapiens
18 DCTN4 51164
Co-fractionation Homo sapiens
19 RAB9A 9367
Proximity Label-MS Homo sapiens
20 COG3 83548
Co-fractionation Homo sapiens
21 HAX1  
Affinity Capture-MS Homo sapiens
22 PDZK1 5174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
23 UBXN6 80700
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AKAP10 is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome
Hemostasis TAS Reactome





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