Gene description for AKAP10
Gene name A kinase (PRKA) anchor protein 10
Gene symbol AKAP10
Other names/aliases AKAP-10
D-AKAP-2
D-AKAP2
PRKA10
Species Homo sapiens
 Database cross references - AKAP10
ExoCarta ExoCarta_11216
Vesiclepedia VP_11216
Entrez Gene 11216
HGNC 368
MIM 604694
UniProt O43572  
 AKAP10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for AKAP10
Biological Process
    signal transduction GO:0007165 TAS
    blood coagulation GO:0007596 TAS
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    protein localization GO:0008104 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IBA
 Experiment description of studies that identified AKAP10 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AKAP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKAR1A 5573
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 PRKAR2B 5577
Invitro Homo sapiens
3 PDZK1 5174
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 PRKAR2A 5576
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which AKAP10 is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome





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