Gene description for ZNF335
Gene name zinc finger protein 335
Gene symbol ZNF335
Other names/aliases MCPH10
NIF-1
NIF1
NIF2
Species Homo sapiens
 Database cross references - ZNF335
ExoCarta ExoCarta_63925
Entrez Gene 63925
HGNC 15807
MIM 610827
UniProt Q9H4Z2  
 ZNF335 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZNF335
Molecular Function
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    protein binding GO:0005515 IPI
    transcription regulatory region DNA binding GO:0044212 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of histone H3-K4 methylation GO:0051569 IEA
    transcription, DNA-templated GO:0006351 IEA
    brain morphogenesis GO:0048854 IEA
    positive regulation of neurogenesis GO:0050769 IMP
    neuron projection morphogenesis GO:0048812 ISS
    regulation of transcription, DNA-templated GO:0006355 IEA
    histone H3-K4 trimethylation GO:0080182 IMP
    cerebral cortex neuron differentiation GO:0021895 IEA
    positive regulation of lymphocyte proliferation GO:0050671 IMP
    in utero embryonic development GO:0001701 IEA
    brain development GO:0007420 IMP
    positive regulation of neuroblast proliferation GO:0002052 ISS
    regulation of gene expression, epigenetic GO:0040029 IMP
Subcellular Localization
    nucleus GO:0005634 ISS
    histone methyltransferase complex GO:0035097 IDA
 Experiment description of studies that identified ZNF335 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZNF335
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCOA6  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF335 is involved
No pathways found





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