Gene description for Rqcd1
Gene name Rcd1 required for cell differentiation1 homolog (S. pombe)
Gene symbol Rqcd1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rqcd1
ExoCarta ExoCarta_301513
Vesiclepedia VP_301513
Entrez Gene 301513
UniProt Q5PQL2  
 Rqcd1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Rqcd1
Molecular Function
    epidermal growth factor receptor binding GO:0005154 ISO
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 ISO
    protein domain specific binding GO:0019904 ISO
    nuclear receptor coactivator activity GO:0030374 ISO
    nuclear receptor coactivator activity GO:0030374 ISS
    protein homodimerization activity GO:0042803 ISO
Biological Process
    mRNA catabolic process GO:0006402 IEA
    biological_process GO:0008150 ND
    negative regulation of translation GO:0017148 IBA
    cytokine-mediated signaling pathway GO:0019221 ISO
    regulatory ncRNA-mediated gene silencing GO:0031047 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 ISO
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 ISS
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 ISO
    positive regulation of DNA-templated transcription GO:0045893 IEA
Subcellular Localization
    P-body GO:0000932 IBA
    P-body GO:0000932 IEA
    P-body GO:0000932 ISO
    P-body GO:0000932 ISS
    nucleus GO:0005634 IEA
    CCR4-NOT complex GO:0030014 IEA
    CCR4-NOT complex GO:0030014 ISO
    CCR4-NOT complex GO:0030014 ISS
    CCR4-NOT core complex GO:0030015 IBA
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Rqcd1 in exosomes
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rqcd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF335 63925
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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