Gene description for SHOC2
Gene name soc-2 suppressor of clear homolog (C. elegans)
Gene symbol SHOC2
Other names/aliases SIAA0862
SOC2
SUR8
Species Homo sapiens
 Database cross references - SHOC2
ExoCarta ExoCarta_8036
Entrez Gene 8036
HGNC 15454
MIM 602775
UniProt Q9UQ13  
 SHOC2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SHOC2
Molecular Function
    protein phosphatase regulator activity GO:0019888 TAS
    protein phosphatase binding GO:0019903 IDA
Biological Process
    regulation of catalytic activity GO:0050790 TAS
    positive regulation of Ras protein signal transduction GO:0046579 IMP
    fibroblast growth factor receptor signaling pathway GO:0008543 NAS
    Ras protein signal transduction GO:0007265 NAS
Subcellular Localization
    protein phosphatase type 1 complex GO:0000164 IDA
    cytoplasm GO:0005737 NAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified SHOC2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SHOC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRAS 4893
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 RAF1 5894
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 HRAS 3265
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 KRAS 3845
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SHOC2 is involved
No pathways found





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