Gene description for TBC1D21
Gene name TBC1 domain family, member 21
Gene symbol TBC1D21
Other names/aliases MgcRabGAP
Species Homo sapiens
 Database cross references - TBC1D21
ExoCarta ExoCarta_161514
Vesiclepedia VP_161514
Entrez Gene 161514
HGNC 28536
UniProt Q8IYX1  
 TBC1D21 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TBC1D21
Molecular Function
    actin binding GO:0003779 IEA
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IMP
Biological Process
    spermatogenesis GO:0007283 ISS
    sperm axoneme assembly GO:0007288 ISS
    flagellated sperm motility GO:0030317 ISS
    plasma membrane to endosome transport GO:0048227 IBA
    sperm mitochondrial sheath assembly GO:0120317 ISS
    regulation of cilium assembly GO:1902017 IMP
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    cytoskeleton GO:0005856 IEA
    cytoplasmic vesicle GO:0031410 IBA
    extracellular exosome GO:0070062 HDA
    sperm midpiece GO:0097225 ISS
 Experiment description of studies that identified TBC1D21 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TBC1D21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUTM1  
Two-hybrid Homo sapiens
2 KRT37 8688
Two-hybrid Homo sapiens
3 CCNDBP1 23582
Affinity Capture-MS Homo sapiens
4 STMN3  
Two-hybrid Homo sapiens
5 CFAP53  
Two-hybrid Homo sapiens
6 TP53 7157
Negative Genetic Homo sapiens
7 PMF1-BGLAP  
Two-hybrid Homo sapiens
8 KRT35 3886
Two-hybrid Homo sapiens
9 REL 5966
Two-hybrid Homo sapiens
10 GFAP 2670
Two-hybrid Homo sapiens
11 TIMM10  
Two-hybrid Homo sapiens
12 CCDC158 339965
Two-hybrid Homo sapiens
13 SNX7 51375
Two-hybrid Homo sapiens
14 SEPT2 4735
Two-hybrid Homo sapiens
15 APP 351
Reconstituted Complex Homo sapiens
16 PMF1  
Two-hybrid Homo sapiens
17 KRT15 3866
Two-hybrid Homo sapiens
18 OR52N4  
Affinity Capture-MS Homo sapiens
19 KRT38 8687
Two-hybrid Homo sapiens
20 EVI5L  
Two-hybrid Homo sapiens
21 GAS2  
Two-hybrid Homo sapiens
22 TCF12  
Two-hybrid Homo sapiens
23 RIBC1  
Two-hybrid Homo sapiens
24 RAB3IP  
Two-hybrid Homo sapiens
25 GTF2E1 2960
Two-hybrid Homo sapiens
26 MEOX2  
Two-hybrid Homo sapiens
27 KRT40  
Two-hybrid Homo sapiens
28 LCN2 3934
Two-hybrid Homo sapiens
29 NR1D2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TBC1D21 is involved
No pathways found





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