Gene description for TBC1D21
Gene name TBC1 domain family, member 21
Gene symbol TBC1D21
Other names/aliases MgcRabGAP
Species Homo sapiens
 Database cross references - TBC1D21
ExoCarta ExoCarta_161514
Entrez Gene 161514
HGNC 28536
UniProt Q8IYX1  
 TBC1D21 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TBC1D21
Molecular Function
    Rab GTPase binding GO:0017137 IMP
    actin binding GO:0003779 IEA
    GTPase activator activity GO:0005096 IEA
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    regulation of cilium assembly GO:1902017 IMP
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    acrosomal vesicle GO:0001669 IEA
 Experiment description of studies that identified TBC1D21 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TBC1D21
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBC1D21 is involved
No pathways found





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