Gene description for GRM3
Gene name glutamate receptor, metabotropic 3
Gene symbol GRM3
Other names/aliases GLUR3
GPRC1C
MGLUR3
mGlu3
Species Homo sapiens
 Database cross references - GRM3
ExoCarta ExoCarta_2913
Vesiclepedia VP_2913
Entrez Gene 2913
HGNC 4595
MIM 601115
UniProt Q14832  
 GRM3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GRM3
Molecular Function
    G-protein coupled receptor activity GO:0004930 TAS
    calcium channel regulator activity GO:0005246 IEA
    glutamate receptor activity GO:0008066 TAS
    group II metabotropic glutamate receptor activity GO:0001641 IBA
    group III metabotropic glutamate receptor activity GO:0001642 IBA
Biological Process
    synaptic transmission GO:0007268 TAS
    adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 IBA
    regulation of synaptic transmission, glutamatergic GO:0051966 IBA
    negative regulation of adenylate cyclase activity GO:0007194 TAS
Subcellular Localization
    postsynaptic membrane GO:0045211 IEA
    dendritic spine GO:0043197 IEA
    axon GO:0030424 IEA
    postsynaptic density GO:0014069 IEA
    presynaptic membrane GO:0042734 IBA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
    astrocyte projection GO:0097449 IEA
 Experiment description of studies that identified GRM3 in exosomes
1
Experiment ID 126
MISEV standards
EV Biophysical techniques
GAPDH
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GRM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPM1A 5494
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 GRIP1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 SDCBP 6386
Reconstituted Complex Homo sapiens
4 PRKCABP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GRM3 is involved
PathwayEvidenceSource
Class C/3 (Metabotropic glutamate/pheromone receptors) TAS Reactome
G alpha (i) signalling events TAS Reactome





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