Gene description for GDF3
Gene name growth differentiation factor 3
Gene symbol GDF3
Other names/aliases KFS3
MCOP7
MCOPCB6
Species Homo sapiens
 Database cross references - GDF3
ExoCarta ExoCarta_9573
Entrez Gene 9573
HGNC 4218
MIM 606522
UniProt Q9NR23  
 GDF3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF3
Molecular Function
    protein kinase binding GO:0019901 IPI
    growth factor activity GO:0008083 IEA
    transforming growth factor beta receptor binding GO:0005160 IBA
    cytokine activity GO:0005125 IBA
Biological Process
    notochord development GO:0030903 IEA
    in utero embryonic development GO:0001701 IEA
    mesoderm development GO:0007498 IEA
    regulation of cell fate commitment GO:0010453 IDA
    endoderm development GO:0007492 IEA
    skeletal system development GO:0001501 IMP
    primitive streak formation GO:0090009 IEA
    negative regulation of BMP signaling pathway GO:0030514 IDA
    cell development GO:0048468 IBA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    response to dietary excess GO:0002021 IEA
    SMAD protein signal transduction GO:0060395 IBA
    BMP signaling pathway GO:0030509 IBA
    regulation of MAPK cascade GO:0043408 IBA
    somite rostral/caudal axis specification GO:0032525 IEA
    formation of anatomical boundary GO:0048859 IEA
    regulation of apoptotic process GO:0042981 IBA
    growth GO:0040007 IEA
    negative regulation of epidermal cell differentiation GO:0045605 IDA
    negative regulation of myoblast differentiation GO:0045662 IEA
    eye development GO:0001654 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified GDF3 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GDF3 is involved
No pathways found





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