Gene description for GDF3
Gene name growth differentiation factor 3
Gene symbol GDF3
Other names/aliases KFS3
MCOP7
MCOPCB6
Species Homo sapiens
 Database cross references - GDF3
ExoCarta ExoCarta_9573
Vesiclepedia VP_9573
Entrez Gene 9573
HGNC 4218
MIM 606522
UniProt Q9NR23  
 GDF3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF3
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
    protein kinase binding GO:0019901 IPI
Biological Process
    skeletal system development GO:0001501 IMP
    eye development GO:0001654 IMP
    in utero embryonic development GO:0001701 IEA
    response to dietary excess GO:0002021 IEA
    signal transduction GO:0007165 IEA
    endoderm development GO:0007492 IEA
    mesoderm development GO:0007498 IEA
    regulation of cell fate commitment GO:0010453 IDA
    negative regulation of BMP signaling pathway GO:0030514 IDA
    notochord development GO:0030903 IEA
    somite rostral/caudal axis specification GO:0032525 IEA
    positive regulation of fat cell differentiation GO:0045600 ISS
    negative regulation of epidermal cell differentiation GO:0045605 IDA
    negative regulation of myoblast differentiation GO:0045662 IEA
    formation of anatomical boundary GO:0048859 IEA
    primitive streak formation GO:0090009 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified GDF3 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP4R1 9989
Affinity Capture-MS Homo sapiens
2 SELO 83642
Affinity Capture-MS Homo sapiens
3 CALR 811
Affinity Capture-MS Homo sapiens
4 TDGF1  
Reconstituted Complex Homo sapiens
5 PQBP1  
Affinity Capture-MS Homo sapiens
6 NPTX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NUPL1 9818
Affinity Capture-MS Homo sapiens
8 MICB  
Affinity Capture-MS Homo sapiens
9 IDH3B 3420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NUP54 53371
Affinity Capture-MS Homo sapiens
11 PPM1A 5494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 VPS39 23339
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GDF3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here