Gene description for Stk38
Gene name serine/threonine kinase 38
Gene symbol Stk38
Other names/aliases 5830476G13Rik
9530097A09Rik
AA617404
Ndr1
Species Mus musculus
 Database cross references - Stk38
ExoCarta ExoCarta_106504
Vesiclepedia VP_106504
Entrez Gene 106504
UniProt Q91VJ4  
 Stk38 identified in exosomes derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Stk38
Molecular Function
    magnesium ion binding GO:0000287 ISO
    magnesium ion binding GO:0000287 ISS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 ISO
    protein serine/threonine kinase activity GO:0004674 ISS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 ISO
    ATP binding GO:0005524 ISS
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA
    mitogen-activated protein kinase kinase kinase binding GO:0031435 ISO
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone reader activity GO:0140566 ISO
    histone reader activity GO:0140566 ISS
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    UFM1-modified protein reader activity GO:0141185 ISO
    UFM1-modified protein reader activity GO:0141185 ISS
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    DNA damage checkpoint signaling GO:0000077 ISO
    DNA damage checkpoint signaling GO:0000077 ISS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 ISO
    protein phosphorylation GO:0006468 ISS
    DNA damage response GO:0006974 ISO
    DNA damage response GO:0006974 ISS
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 ISO
    intracellular signal transduction GO:0035556 ISS
    protein modification process GO:0036211 ISO
    negative regulation of MAP kinase activity GO:0043407 ISO
    negative regulation of MAP kinase activity GO:0043407 ISS
    postsynapse organization GO:0099173 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    site of double-strand break GO:0035861 ISO
    site of double-strand break GO:0035861 ISS
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Stk38 in exosomes
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Stk38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Jarid2  
Affinity Capture-MS Mus musculus
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Mtf2  
Affinity Capture-MS Mus musculus
4 Myd88  
Affinity Capture-MS Mus musculus
5 STK38 11329
Affinity Capture-MS Homo sapiens
6 MOB1B 92597
Affinity Capture-MS Homo sapiens
7 Eed  
Affinity Capture-MS Mus musculus
8 MOB1A 55233
Affinity Capture-MS Homo sapiens
9 Ezh1  
Affinity Capture-MS Mus musculus
10 MOB2 81532
Affinity Capture-MS Homo sapiens
11 Fancd2  
Affinity Capture-MS Mus musculus
12 Ezh2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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