Gene description for SERPINA4
Gene name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Gene symbol SERPINA4
Other names/aliases KAL
KLST
KST
PI-4
PI4
kallistatin
Species Homo sapiens
 Database cross references - SERPINA4
ExoCarta ExoCarta_5267
Vesiclepedia VP_5267
Entrez Gene 5267
HGNC 8948
MIM 147935
UniProt P29622  
 SERPINA4 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SERPINA4
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    platelet dense granule lumen GO:0031089 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SERPINA4 in sEVs
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SERPINA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GADD45G  
Two-hybrid Homo sapiens
2 RASA1 5921
Two-hybrid Homo sapiens
3 MAP4K2  
Two-hybrid Homo sapiens
4 FDFT1 2222
Affinity Capture-MS Homo sapiens
5 KLK1 3816
Reconstituted Complex Homo sapiens
6 TAB1 10454
Two-hybrid Homo sapiens
7 ILK 3611
Two-hybrid Homo sapiens
8 MAPK6  
Two-hybrid Homo sapiens
9 FKBP14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 YAE1D1  
Two-hybrid Homo sapiens
11 TNFRSF14  
Two-hybrid Homo sapiens
12 CANX 821
Affinity Capture-MS Homo sapiens
13 CTBP1 1487
Affinity Capture-MS Homo sapiens
14 NR4A1  
Two-hybrid Homo sapiens
15 PDPK1 5170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TNNT1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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