Gene description for SERPINA4
Gene name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Gene symbol SERPINA4
Other names/aliases KAL
KLST
KST
PI-4
PI4
kallistatin
Species Homo sapiens
 Database cross references - SERPINA4
ExoCarta ExoCarta_5267
Entrez Gene 5267
HGNC 8948
MIM 147935
UniProt P29622  
 SERPINA4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SERPINA4
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IBA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SERPINA4 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SERPINA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLK2  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
2 KLK1 3816
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SERPINA4 is involved
No pathways found





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