Gene description for Fbxw4
Gene name F-box and WD-40 domain protein 4
Gene symbol Fbxw4
Other names/aliases Dac
Fbw4
SHFM3
SHSF3
dactylin
dactylyn
Species Mus musculus
 Database cross references - Fbxw4
ExoCarta ExoCarta_30838
Entrez Gene 30838
UniProt Q9JMJ2  
 Fbxw4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Fbxw4
Biological Process
    embryonic digit morphogenesis GO:0042733 IMP
    cartilage development GO:0051216 IMP
    Wnt signaling pathway GO:0016055 IEA
    multicellular organismal development GO:0007275 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 IMP
    limb development GO:0060173 IMP
 Experiment description of studies that identified Fbxw4 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Fbxw4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbxw4 is involved
PathwayEvidenceSource
Association of TriC/CCT with target proteins during biosynthesis IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here