Gene description for Cacybp
Gene name calcyclin binding protein
Gene symbol Cacybp
Other names/aliases SIP
Species Mus musculus
 Database cross references - Cacybp
ExoCarta ExoCarta_12301
Vesiclepedia VP_12301
Entrez Gene 12301
UniProt Q9CXW3  
 Cacybp identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cacybp
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    protein binding GO:0005515 IPI
Biological Process
    cardiac muscle cell differentiation GO:0055007 ISO
    positive regulation of DNA replication GO:0045740 ISO
    negative regulation of cell death GO:0060548 ISO
    response to growth hormone GO:0060416 ISO
Subcellular Localization
    cell body GO:0044297 ISO
    beta-catenin destruction complex GO:0030877 ISO
    nucleoplasm GO:0005654 ISO
    nuclear envelope lumen GO:0005641 IDA
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    neuron projection GO:0043005 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cacybp in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cacybp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cacybp is involved
No pathways found





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