Gene description for PDE1C
Gene name phosphodiesterase 1C, calmodulin-dependent 70kDa
Gene symbol PDE1C
Other names/aliases Hcam3
cam-PDE 1C
hCam-3
Species Homo sapiens
 Database cross references - PDE1C
ExoCarta ExoCarta_5137
Vesiclepedia VP_5137
Entrez Gene 5137
HGNC 8776
MIM 602987
UniProt Q14123  
 PDE1C identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for PDE1C
Molecular Function
    3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 IDA
    calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity GO:0004117 IBA
    calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity GO:0004117 IDA
    calmodulin binding GO:0005516 IEA
    metal ion binding GO:0046872 IEA
    3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 IDA
    calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity GO:0048101 IBA
Biological Process
    cAMP-mediated signaling GO:0019933 IBA
Subcellular Localization
    lysosome GO:0005764 ISS
    cytosol GO:0005829 TAS
    neuronal cell body GO:0043025 IBA
 Experiment description of studies that identified PDE1C in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PDE1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDE1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GSPT2 23708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 EGFR 1956
Affinity Capture-MS Homo sapiens
4 KIF14 9928
Affinity Capture-MS Homo sapiens
5 WWP1 11059
Affinity Capture-MS Homo sapiens
6 PDE1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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