Gene description for Gnas
Gene name	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Gene symbol	Gnas
Other names/aliases	5530400H20Rik A930027G11Rik C130027O20Rik GPSA GSP Galphas Gnas1 Gnasxl Gsa Nesp Nespl Oed-Sml Oedsml P1 P2 P3 PHP1A PHP1B POH
Species	Mus musculus
Database cross references - Gnas
ExoCarta	ExoCarta_14683
Entrez Gene	14683
UniProt	Q6R0H6   Q6R0H7   P63094   Q9Z0F1
Gnas identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts	18494037
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846
Mov neuroglial cells	15210972

Gene ontology annotations for Gnas

Molecular Function     G-protein beta-subunit binding GO:0031681 ISO     GTP binding GO:0005525 ISO     alpha-tubulin binding GO:0043014 ISO     nucleotide binding GO:0000166 IEA     signal transducer activity GO:0004871 ISO     G-protein alpha-subunit binding GO:0001965 ISO     D1 dopamine receptor binding GO:0031748 ISO     corticotropin-releasing hormone receptor 1 binding GO:0051430 ISO     protein binding GO:0005515 IPI     insulin-like growth factor receptor binding GO:0005159 ISO     G-protein beta/gamma-subunit complex binding GO:0031683 IBA     guanyl nucleotide binding GO:0019001 IEA     mu-type opioid receptor binding GO:0031852 ISO     GTPase activity GO:0003924 TAS     protein domain specific binding GO:0019904 ISO     beta-2 adrenergic receptor binding GO:0031698 ISO     metal ion binding GO:0046872 IEA     ionotropic glutamate receptor binding GO:0035255 ISO Biological Process     signal transduction GO:0007165 IBA     regulation of transcription from RNA polymerase II promoter GO:0006357 ISO     platelet aggregation GO:0070527 ISO     adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 ISO     energy reserve metabolic process GO:0006112 IMP     tissue homeostasis GO:0001894 IMP     positive regulation of cAMP-mediated signaling GO:0043950 ISO     response to drug GO:0042493 IMP     response to parathyroid hormone GO:0071107 ISO     positive regulation of GTPase activity GO:0043547 ISO     cartilage development GO:0051216 IMP     embryonic hindlimb morphogenesis GO:0035116 IMP     adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 ISO     negative regulation of renal sodium excretion GO:0035814 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of cAMP biosynthetic process GO:0030819 ISO     negative regulation of blood pressure GO:0045776 ISO     skeletal system development GO:0001501 IMP     regulation of signal transduction GO:0009966 ISO     positive regulation of sodium ion transport GO:0010765 ISO     cellular response to catecholamine stimulus GO:0071870 ISO     multicellular organism growth GO:0035264 IMP     positive regulation of osteoclast differentiation GO:0045672 IMP     cognition GO:0050890 ISO     cellular response to prostaglandin E stimulus GO:0071380 ISO     sensory perception of chemical stimulus GO:0007606 IBA     DNA methylation GO:0006306 IMP     developmental growth GO:0048589 ISO     endochondral ossification GO:0001958 IMP     post-embryonic development GO:0009791 IMP     embryonic cranial skeleton morphogenesis GO:0048701 IMP     skin development GO:0043588 IMP     adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 ISO     positive regulation of osteoblast differentiation GO:0045669 IMP     G-protein coupled receptor signaling pathway GO:0007186 TAS     genetic imprinting GO:0071514 IMP     post-embryonic body morphogenesis GO:0040032 IMP     negative regulation of multicellular organism growth GO:0040015 IMP     hair follicle placode formation GO:0060789 ISO     bone development GO:0060348 ISO     calcium ion homeostasis GO:0055074 ISO Subcellular Localization     extracellular region GO:0005576 IEA     dendrite GO:0030425 IDA     plasma membrane GO:0005886 ISO     intrinsic component of membrane GO:0031224 ISO     extracellular exosome GO:0070062 ISO     nucleus GO:0005634 ISO     sarcolemma GO:0042383 ISO     cytoplasm GO:0005737 ISO     perinuclear region of cytoplasm GO:0048471 ISO     cell projection GO:0042995 IEA     heterotrimeric G-protein complex GO:0005834 TAS     cytoplasmic vesicle GO:0031410 IEA     membrane raft GO:0045121 ISO     membrane GO:0016020 ISO     vesicle GO:0031982 ISO     trans-Golgi network membrane GO:0032588 ISO     cytosol GO:0005829 ISO     ruffle GO:0001726 ISO     endosome GO:0005768 ISO