Gene description for Prickle1
Gene name prickle homolog 1 (Drosophila)
Gene symbol Prickle1
Other names/aliases 1110058P22Rik
AW215793
Prickle
b2b019Clo
mpk1
Species Mus musculus
 Database cross references - Prickle1
ExoCarta ExoCarta_106042
Vesiclepedia VP_106042
Entrez Gene 106042
UniProt Q3U5C7  
 Prickle1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Prickle1
Molecular Function
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    transcription factor binding GO:0008134 ISO
Biological Process
    positive regulation of protein ubiquitination GO:0031398 ISO
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    negative regulation of cardiac muscle cell myoblast differentiation GO:2000691 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    neural tube closure GO:0001843 ISO
    protein import into nucleus GO:0006606 ISO
Subcellular Localization
    cytosol GO:0005829 ISO
    nuclear membrane GO:0031965 ISO
    nucleus GO:0005634 ISO
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Prickle1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Prickle1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prickle1 is involved
PathwayEvidenceSource
Asymmetric localization of PCP proteins IEA Reactome





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