Gene description for SLC13A3
Gene name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Gene symbol SLC13A3
Other names/aliases NADC3
SDCT2
Species Homo sapiens
 Database cross references - SLC13A3
ExoCarta ExoCarta_64849
Vesiclepedia VP_64849
Entrez Gene 64849
HGNC 14430
MIM 606411
UniProt Q8WWT9  
 SLC13A3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 19056867    
 Gene ontology annotations for SLC13A3
Molecular Function
    dicarboxylic acid transmembrane transporter activity GO:0005310 IDA
    dicarboxylic acid transmembrane transporter activity GO:0005310 TAS
    protein binding GO:0005515 IPI
    citrate transmembrane transporter activity GO:0015137 IBA
    citrate transmembrane transporter activity GO:0015137 ISS
    alpha-ketoglutarate transmembrane transporter activity GO:0015139 IDA
    succinate transmembrane transporter activity GO:0015141 IBA
    succinate transmembrane transporter activity GO:0015141 IDA
    succinate transmembrane transporter activity GO:0015141 TAS
    high-affinity sodium:dicarboxylate symporter activity GO:0015362 TAS
    sodium:dicarboxylate symporter activity GO:0017153 IBA
    sodium:dicarboxylate symporter activity GO:0017153 IDA
    sodium:dicarboxylate symporter activity GO:0017153 TAS
    glutathione transmembrane transporter activity GO:0034634 IDA
Biological Process
    dicarboxylic acid transport GO:0006835 IDA
    dicarboxylic acid transport GO:0006835 TAS
    lipid transport GO:0006869 IEA
    alpha-ketoglutarate transport GO:0015742 IEA
    citrate transport GO:0015746 IBA
    citrate transport GO:0015746 ISS
    glutathione transmembrane transport GO:0034775 IDA
    sodium ion transmembrane transport GO:0035725 IEA
    succinate transmembrane transport GO:0071422 IBA
    succinate transmembrane transport GO:0071422 IDA
    succinate transmembrane transport GO:0071422 TAS
    transport across blood-brain barrier GO:0150104 NAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC13A3 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC13A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CISD2 493856
Two-hybrid Homo sapiens
2 LEUTX  
Two-hybrid Homo sapiens
3 FAM209A 200232
Two-hybrid Homo sapiens
4 ERGIC3 51614
Two-hybrid Homo sapiens
5 GPX8 493869
Two-hybrid Homo sapiens
6 ARL13B 200894
Two-hybrid Homo sapiens
7 RMDN3 55177
Two-hybrid Homo sapiens
8 CREB3L1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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