Gene description for SLC13A3
Gene name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Gene symbol SLC13A3
Other names/aliases NADC3
SDCT2
Species Homo sapiens
 Database cross references - SLC13A3
ExoCarta ExoCarta_64849
Vesiclepedia VP_64849
Entrez Gene 64849
HGNC 14430
MIM 606411
UniProt Q8WWT9  
 SLC13A3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 19056867    
 Gene ontology annotations for SLC13A3
Molecular Function
    high-affinity sodium:dicarboxylate symporter activity GO:0015362 IEA
Biological Process
    transmembrane transport GO:0055085 TAS
    sodium ion transport GO:0006814 IEA
    dicarboxylic acid transport GO:0006835 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLC13A3 in exosomes
1
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 63
MISEV standards
EV Biophysical techniques
AQP2
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC13A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC13A3 is involved
PathwayEvidenceSource
Sodium-coupled sulphate, di- and tri-carboxylate transporters TAS Reactome





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