ZNF185 
                                                                        
                                                                            
                                                                                
                                                                         
                                                                     
                                                            
                                                            
                                                         
                                                        
                                                        
                                                            
                                                                ZNF185  in sEVs
                                                                                
                                                                                    
                                                                                        
                                                                                            1 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        412 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX|ACTB
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MCF7 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            2 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        414 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MDA-MB-231 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            3 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        426 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MDA-MB-231  - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            4 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        427 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Breast cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MDA-MB-231 - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            5 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        407 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            6 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        419 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            7 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        419 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            8 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        420 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            9 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        420 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Embryonic kidney cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HEK293T - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            10 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        405 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Foreskin fibroblasts 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BJ  
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            11 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        417 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX|ACTB
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Lymphoma cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Raji 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            12 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        411 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Mammary cancer-associated fibroblasts 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        mCAF 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            13 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        418 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Monocytic leukemia cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        THP-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            14 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        418 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Monocytic leukemia cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        THP-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            15 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        413 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Normal mammary epithelial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        MCF10A 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            16 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        406 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        BxPC3 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            17 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        415 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PANC-1 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            18 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        434 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PANC-1  - Exo-rich fractions 7-10 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Western blotting 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            19 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        435 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic cancer cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PANC-1 - Exo-rich fractions 1-6 pooled 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            20 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        408 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX|ACTB
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic duct epithalial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HPDE 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            21 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        409 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pancreatic duct epithalial cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        HPNE 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            22 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        416 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Pluripotent stem cells 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        PSC 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            23 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        410 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                CANX
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            Protein
                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            34108659
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            Nat Cell Biol 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2021 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        T lymphocytes 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Jurkat 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        RT-qPCR 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                            
                                                                            
                                                                                
                                                                                    
                                                                                        
                                                                                            24 
                                                                                            
                                                                                                
                                                                                                    
                                                                                                        Experiment ID 
                                                                                                        217 
                                                                                                        
                                                                                                            
                                                                                                                
                                                                                                                    MISEV standards 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                EM
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Biophysical techniques 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                TSG101|CD81|CD9|CD63
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    Enriched markers 
                                                                                                                 
                                                                                                               
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                            ✘ 
                                                                                                                                                                                                                                             
                                                                                                                    Negative markers 
                                                                                                                 
                                                                                                                
                                                                                                                    
                                                                                                                                                                                                                                                    ✔ 
                                                                                                                            
                                                                                                                                NTA
                                                                                                                            
                                                                                                                            
                                                                                                                                                                                                                                                                                                                                                                     
                                                                                                                    
                                                                                                                        Particle analysis
                                                                                                                     
                                                                                                                 
                                                                                                            
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Identified molecule 
                                                                                                        
                                                                                                            protein
                                                                                                                                                                                                                                     
                                                                                                     
                                                                                                    
                                                                                                        Identification method 
                                                                                                        
                                                                                                                                                                                                                            Mass spectrometry
                                                                                                                                                                                                                             
                                                                                                     
                                                                                                    
                                                                                                        PubMed ID 
                                                                                                        
                                                                                                                                                                                                                            23844026
                                                                                                                        
                                                                                                     
                                                                                                    
                                                                                                        Organism 
                                                                                                        Homo sapiens 
                                                                                                     
                                                                                                    
                                                                                                        Experiment description 
                                                                                                        Characterization of human thymic exosomes. 
                                                                                                     
                                                                                                    
                                                                                                        Authors 
                                                                                                        "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O." 
                                                                                                     
                                                                                                    
                                                                                                        Journal name 
                                                                                                        
                                                                                                                                                                                                                            PLoS One 
                                                                                                                                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Publication year 
                                                                                                        2013 
                                                                                                     
                                                                                                    
                                                                                                        Sample 
                                                                                                        Thymus 
                                                                                                     
                                                                                                    
                                                                                                        Sample name 
                                                                                                        Normal-Thymus 
                                                                                                     
                                                                                                    
                                                                                                    
                                                                                                        Isolation/purification methods 
                                                                                                        Differential centrifugation 
                                                                                                     
                                                                                                    
                                                                                                        Flotation density 
                                                                                                        
                                                                                                                                                                                                                                                                                                                                        -
                                                                                                                                                                                                                        
                                                                                                         
                                                                                                     
                                                                                                    
                                                                                                        Molecules identified in the study 
                                                                                                        Protein 
                                                                                                     
                                                                                                    
                                                                                                        Methods used in the study 
                                                                                                        Mass spectrometry 
                                                                                                     
                                                                                                
                                                                                             
                                                                                         
                                                                                    
                                                                                 
                                                                             
                                                                                                                                
                                                         
                                                        
                                                        
                                                        
                                                            
                                                                
                                                                    
                                                                        
                                                                            ZNF185 
                                                                                
                                                                                    
                                                                                        
                                                                                              
                                                                                            Protein Interactor 
                                                                                            ExoCarta ID 
                                                                                            Identification method 
                                                                                            PubMed 
                                                                                            Species 
                                                                                         
                                                                                                                                                                                    
                                                                                                
                                                                                                    1 
                                                                                                                                                                                                            PIH1D2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    2 
                                                                                                                                                                                                                PPP2R2B 
                                                                                                            5521 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    3 
                                                                                                                                                                                                            C18orf21 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    4 
                                                                                                                                                                                                            DHDH 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    5 
                                                                                                                                                                                                                AGPAT1 
                                                                                                            10554 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    6 
                                                                                                                                                                                                            HSF2BP 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    7 
                                                                                                                                                                                                            NRSN1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    8 
                                                                                                                                                                                                                MRPL27 
                                                                                                            51264 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    9 
                                                                                                                                                                                                                ALDH1B1 
                                                                                                            219 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    10 
                                                                                                                                                                                                                SEPT9 
                                                                                                            10801 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    11 
                                                                                                                                                                                                                EMILIN1 
                                                                                                            11117 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    12 
                                                                                                                                                                                                                CUL3 
                                                                                                            8452 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    13 
                                                                                                                                                                                                                UBE3A 
                                                                                                            7337 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Affinity Capture-Western 
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                        Co-localization 
                                                                                                                                        Homo sapiens 
                                                                                                                                                                                                                                                             
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-Western 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    14 
                                                                                                                                                                                                            CDK15 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    15 
                                                                                                                                                                                                            PRR23B 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    16 
                                                                                                                                                                                                                KLRG2 
                                                                                                            346689 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    17 
                                                                                                                                                                                                            SOX2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    18 
                                                                                                                                                                                                            FNDC5 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    19 
                                                                                                                                                                                                            RNF38 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    20 
                                                                                                                                                                                                                APEX1 
                                                                                                            328 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-RNA 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    21 
                                                                                                                                                                                                                SRRT 
                                                                                                            51593 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    22 
                                                                                                                                                                                                            LMO2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    23 
                                                                                                                                                                                                                MBNL1 
                                                                                                            4154 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    24 
                                                                                                                                                                                                                CDH1 
                                                                                                            999 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Proximity Label-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    25 
                                                                                                                                                                                                                RPA3 
                                                                                                            6119 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Proximity Label-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    26 
                                                                                                                                                                                                            IL12RB1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    27 
                                                                                                                                                                                                                PIGT 
                                                                                                            51604 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    28 
                                                                                                                                                                                                                CBX8 
                                                                                                            57332 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    29 
                                                                                                                                                                                                                GOT1 
                                                                                                            2805 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    30 
                                                                                                                                                                                                                WIPI1 
                                                                                                            55062 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    31 
                                                                                                                                                                                                                COPS5 
                                                                                                            10987 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    32 
                                                                                                                                                                                                            SSUH2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    33 
                                                                                                                                                                                                                BICD2 
                                                                                                            23299 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Proximity Label-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    34 
                                                                                                                                                                                                                PTGES3L-AARSD1 
                                                                                                            100885850 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    35 
                                                                                                                                                                                                                OR2A4 
                                                                                                            79541 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    36 
                                                                                                                                                                                                            CEP76 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Two-hybrid 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    37 
                                                                                                                                                                                                            CCR1 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    38 
                                                                                                                                                                                                            TRMU 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    39 
                                                                                                                                                                                                                HNRNPA3 
                                                                                                            220988 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Co-fractionation 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    40 
                                                                                                                                                                                                                STX17 
                                                                                                            55014 
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                    
                                                                                                
                                                                                                    41 
                                                                                                                                                                                                            ETNK2 
                                                                                                          
                                                                                                        
                                                                                                    
                                                                                                        
                                                                                                            
                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                                                                                                                                                                    Affinity Capture-MS 
                                                                                                                                    Homo sapiens 
                                                                                                                                                                                                                                                                 
                                                                                                                                                                                                                        
                                                                                                     
                                                                                             
                                                                                                                                                                                                                                                                                
                                                                                                    
                                                                                                        View the network 
                                                                                                     
                                                                                                    
                                                                                                        
                                                                                                                    
                                                                                                                    
                                                                                                                        
                                                                                                                        
                                                                                                                            
                                                                                                                            image/svg+xml 
                                                                                                                             
                                                                                                                         
                                                                                                                         
                                                                                                                         
                                                                                                         
                                                                                                     
                                                                                                 
                                                                                                                                                                            
                                                                                 
                                                                             
                                                            
                                                         
                                                        
                                                        
                                                        
                                                            
                                                                
                                                                    
                                                                        ZNF185  is involved
                                                                            
                                                                                                                                                                            No pathways found