Gene description for TRMT11
Gene name tRNA methyltransferase 11 homolog (S. cerevisiae)
Gene symbol TRMT11
Other names/aliases C6orf75
MDS024
TRM11
TRMT11-1
Species Homo sapiens
 Database cross references - TRMT11
ExoCarta ExoCarta_60487
Vesiclepedia VP_60487
Entrez Gene 60487
HGNC 21080
UniProt Q7Z4G4  
 TRMT11 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TRMT11
Molecular Function
    tRNA binding GO:0000049 IEA
    protein binding GO:0005515 IPI
    methyltransferase activity GO:0008168 IBA
    tRNA (guanine(10)-N2)-methyltransferase activity GO:0160102 IEA
Biological Process
    tRNA processing GO:0008033 IEA
    methylation GO:0032259 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
 Experiment description of studies that identified TRMT11 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRMT11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 CLPP 8192
Proximity Label-MS Homo sapiens
3 CS 1431
Proximity Label-MS Homo sapiens
4 RAMP2  
Affinity Capture-MS Homo sapiens
5 MRRF  
Proximity Label-MS Homo sapiens
6 NARS 4677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TP53 7157
Affinity Capture-Western Homo sapiens
8 MDH2 4191
Proximity Label-MS Homo sapiens
9 VTN 7448
Affinity Capture-MS Homo sapiens
10 DNAJA2 10294
Affinity Capture-MS Homo sapiens
11 PLAUR 5329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SSX6  
Affinity Capture-MS Homo sapiens
13 COX8A  
Proximity Label-MS Homo sapiens
14 HTR2C  
Affinity Capture-MS Homo sapiens
15 TRMT112 51504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 C21orf33  
Proximity Label-MS Homo sapiens
17 TP73  
Affinity Capture-Western Homo sapiens
18 MTRF1  
Proximity Label-MS Homo sapiens
19 WDR48 57599
Affinity Capture-MS Homo sapiens
20 TBRG4 9238
Proximity Label-MS Homo sapiens
21 AARS2  
Proximity Label-MS Homo sapiens
22 RPA3 6119
Proximity Label-MS Homo sapiens
23 GALC 2581
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TP63  
Affinity Capture-Western Homo sapiens
25 AKR7A3 22977
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 HSPD1 3329
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRMT11 is involved
PathwayEvidenceSource
Metabolism of RNA IEA Reactome
tRNA modification in the nucleus and cytosol IEA Reactome
tRNA processing IEA Reactome





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