Gene description for AZU1
Gene name azurocidin 1
Gene symbol AZU1
Other names/aliases AZAMP
AZU
CAP37
HBP
HUMAZUR
NAZC
Species Homo sapiens
 Database cross references - AZU1
ExoCarta ExoCarta_566
Entrez Gene 566
HGNC 913
MIM 162815
UniProt P20160  
 AZU1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for AZU1
Molecular Function
    heparin binding GO:0008201 NAS
    toxic substance binding GO:0015643 NAS
    serine-type endopeptidase activity GO:0004252 IBA
Biological Process
    protein processing GO:0016485 IBA
    positive regulation of MHC class II biosynthetic process GO:0045348 IEP
    monocyte activation GO:0042117 TAS
    immune response GO:0006955 IBA
    positive regulation of fractalkine biosynthetic process GO:0050754 IDA
    cellular extravasation GO:0045123 NAS
    positive regulation of interleukin-1 beta biosynthetic process GO:0050725 IDA
    defense response to Gram-negative bacterium GO:0050829 TAS
    glial cell migration GO:0008347 IDA
    induction of positive chemotaxis GO:0050930 NAS
    inflammatory response GO:0006954 NAS
    macrophage chemotaxis GO:0048246 NAS
    regulation of vascular permeability GO:0043114 NAS
    negative regulation of apoptotic process GO:0043066 NAS
    positive regulation of phagocytosis GO:0050766 IDA
    microglial cell activation GO:0001774 IEP
    protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 TAS
    positive regulation of cell adhesion GO:0045785 IDA
    positive regulation of tumor necrosis factor biosynthetic process GO:0042535 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    extracellular region GO:0005576 NAS
    azurophil granule GO:0042582 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified AZU1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for AZU1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AZU1 is involved
No pathways found





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