Gene description for EPHA5
Gene name EPH receptor A5
Gene symbol EPHA5
Other names/aliases CEK7
Species Homo sapiens
 Database cross references - EPHA5
ExoCarta ExoCarta_2044
Entrez Gene 2044
HGNC 3389
MIM 600004
UniProt P54756  
 EPHA5 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for EPHA5
Molecular Function
    GPI-linked ephrin receptor activity GO:0005004 ISS
    ephrin receptor activity GO:0005003 ISS
    ATP binding GO:0005524 IEA
    transmembrane-ephrin receptor activity GO:0005005 NAS
Biological Process
    regulation of GTPase activity GO:0043087 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 ISS
    hippocampus development GO:0021766 ISS
    ephrin receptor signaling pathway GO:0048013 TAS
    axon guidance GO:0007411 TAS
    neuron development GO:0048666 IEP
    positive regulation of CREB transcription factor activity GO:0032793 ISS
    cAMP-mediated signaling GO:0019933 ISS
    regulation of actin cytoskeleton organization GO:0032956 ISS
Subcellular Localization
    neuronal cell body GO:0043025 IDA
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IEA
    external side of plasma membrane GO:0009897 IDA
    integral component of plasma membrane GO:0005887 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    rough endoplasmic reticulum GO:0005791 IDA
    dendrite GO:0030425 IDA
 Experiment description of studies that identified EPHA5 in exosomes
Experiment ID 21
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for EPHA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STAT3 6774
Affinity Capture-Western Homo sapiens
2 EFNA1  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which EPHA5 is involved
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
EPHA-mediated growth cone collapse TAS Reactome

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