Gene description for TMEM179B
Gene name transmembrane protein 179B
Gene symbol TMEM179B
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM179B
ExoCarta ExoCarta_374395
Vesiclepedia VP_374395
Entrez Gene 374395
HGNC 33744
UniProt Q7Z7N9  
 TMEM179B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM179B
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    nucleolus GO:0005730 IDA
    plasma membrane GO:0005886 TAS
    nuclear speck GO:0016607 IDA
    secretory granule membrane GO:0030667 TAS
    azurophil granule membrane GO:0035577 TAS
    ficolin-1-rich granule membrane GO:0101003 TAS
 Experiment description of studies that identified TMEM179B in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM179B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GUCA2A  
Two-hybrid Homo sapiens
2 PTGIR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RGS9BP  
Affinity Capture-MS Homo sapiens
4 LRP10 26020
Two-hybrid Homo sapiens
5 FAM189B  
Affinity Capture-MS Homo sapiens
6 CLDN1 9076
Two-hybrid Homo sapiens
7 TMEM107 84314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CLCN7 1186
Two-hybrid Homo sapiens
9 C2CD2L 9854
Two-hybrid Homo sapiens
10 GPR151  
Two-hybrid Homo sapiens
11 ZDHHC9  
Affinity Capture-MS Homo sapiens
12 CCDC167  
Two-hybrid Homo sapiens
13 CHRNA4  
Affinity Capture-MS Homo sapiens
14 TTYH1  
Affinity Capture-MS Homo sapiens
15 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CD68 968
Two-hybrid Homo sapiens
17 OR10H2  
Affinity Capture-MS Homo sapiens
18 FAM163A  
Two-hybrid Homo sapiens
19 SLC1A1 6505
Two-hybrid Homo sapiens
20 TMEM214 54867
Affinity Capture-MS Homo sapiens
21 TM4SF18  
Affinity Capture-MS Homo sapiens
22 KCNK18  
Affinity Capture-MS Homo sapiens
23 TM4SF19  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 TUSC5  
Two-hybrid Homo sapiens
25 CCL4L2  
Two-hybrid Homo sapiens
26 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SLC39A8 64116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ERGIC3 51614
Two-hybrid Homo sapiens
30 PLN  
Two-hybrid Homo sapiens
31 CHRM4  
Affinity Capture-MS Homo sapiens
32 TMEM236  
Two-hybrid Homo sapiens
33 MFSD5  
Two-hybrid Homo sapiens
34 STEAP3 55240
Affinity Capture-MS Homo sapiens
35 TMX1 81542
Affinity Capture-MS Homo sapiens
36 IGFBP5 3488
Two-hybrid Homo sapiens
37 HNRNPR 10236
Co-fractionation Homo sapiens
38 GPR114  
Affinity Capture-MS Homo sapiens
39 PTPN1 5770
Affinity Capture-MS Homo sapiens
40 TMC4  
Affinity Capture-MS Homo sapiens
41 HNRNPUL1 11100
Co-fractionation Homo sapiens
42 SERP2  
Two-hybrid Homo sapiens
43 OR4N2  
Affinity Capture-MS Homo sapiens
44 SMIM5  
Affinity Capture-MS Homo sapiens
45 TMEM242  
Two-hybrid Homo sapiens
46 MFSD6 54842
Two-hybrid Homo sapiens
47 OR4Q3  
Affinity Capture-MS Homo sapiens
48 SIDT2 51092
Affinity Capture-MS Homo sapiens
49 BTN2A2  
Two-hybrid Homo sapiens
50 GOLIM4 27333
Affinity Capture-MS Homo sapiens
51 LYG1  
Two-hybrid Homo sapiens
52 GPR52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ADIPOQ 9370
Two-hybrid Homo sapiens
54 NMUR2  
Affinity Capture-MS Homo sapiens
55 TMEM237 65062
Two-hybrid Homo sapiens
56 KRTAP12-2  
Two-hybrid Homo sapiens
57 CCL4  
Two-hybrid Homo sapiens
58 OR52I1  
Affinity Capture-MS Homo sapiens
59 SLC7A14  
Affinity Capture-MS Homo sapiens
60 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 TMEM47 83604
Two-hybrid Homo sapiens
62 GKN1  
Two-hybrid Homo sapiens
63 TSPAN16  
Affinity Capture-MS Homo sapiens
64 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CTXN3  
Two-hybrid Homo sapiens
66 STX8 9482
Two-hybrid Homo sapiens
67 GALNT15  
Two-hybrid Homo sapiens
68 OR10S1  
Affinity Capture-MS Homo sapiens
69 KTN1 3895
Two-hybrid Homo sapiens
70 NKAIN1  
Affinity Capture-MS Homo sapiens
71 SCAMP1 9522
Affinity Capture-MS Homo sapiens
72 UPK1A 11045
Affinity Capture-MS Homo sapiens
73 FATE1  
Two-hybrid Homo sapiens
74 CCL3L3  
Two-hybrid Homo sapiens
75 SLC52A1  
Two-hybrid Homo sapiens
76 LRRC8B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 FCER1G 2207
Two-hybrid Homo sapiens
78 C3orf52  
Two-hybrid Homo sapiens
79 C1QL4  
Two-hybrid Homo sapiens
80 CLDN6 9074
Two-hybrid Homo sapiens
81 SLC47A1  
Affinity Capture-MS Homo sapiens
82 CLRN2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM179B is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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