Gene description for EPT1
Gene name ethanolaminephosphotransferase 1
Gene symbol EPT1
Other names/aliases SELI
SEPI
Species Homo sapiens
 Database cross references - EPT1
ExoCarta ExoCarta_85465
Entrez Gene 85465
HGNC 29361
MIM 607915
UniProt Q9C0D9  
 EPT1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for EPT1
Molecular Function
    ethanolaminephosphotransferase activity GO:0004307 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylethanolamine biosynthetic process GO:0006646 TAS
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    glycerophospholipid biosynthetic process GO:0046474 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified EPT1 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for EPT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which EPT1 is involved
PathwayEvidenceSource
Synthesis of PE TAS Reactome





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