Gene description for CETP
Gene name cholesteryl ester transfer protein, plasma
Gene symbol CETP
Other names/aliases BPIFF
HDLCQ10
Species Homo sapiens
 Database cross references - CETP
ExoCarta ExoCarta_1071
Vesiclepedia VP_1071
Entrez Gene 1071
HGNC 1869
MIM 118470
UniProt P11597  
 CETP identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Urine 19056867    
 Gene ontology annotations for CETP
Molecular Function
    phospholipid transporter activity GO:0005548 IBA
    phospholipid transporter activity GO:0005548 IDA
    lipid binding GO:0008289 IDA
    cholesterol binding GO:0015485 IBA
    cholesterol binding GO:0015485 IDA
    triglyceride binding GO:0017129 IBA
    triglyceride binding GO:0017129 IDA
    phosphatidylcholine binding GO:0031210 IBA
    phosphatidylcholine binding GO:0031210 IDA
    cholesterol transfer activity GO:0120020 IDA
Biological Process
    triglyceride metabolic process GO:0006641 IBA
    triglyceride metabolic process GO:0006641 IDA
    lipid transport GO:0006869 IDA
    cholesterol metabolic process GO:0008203 IBA
    cholesterol metabolic process GO:0008203 IDA
    cholesterol metabolic process GO:0008203 IMP
    negative regulation of macrophage derived foam cell differentiation GO:0010745 IC
    regulation of cholesterol efflux GO:0010874 IMP
    phospholipid transport GO:0015914 IEA
    cholesterol transport GO:0030301 IDA
    positive regulation of cholesterol transport GO:0032376 IDA
    triglyceride transport GO:0034197 IBA
    triglyceride transport GO:0034197 IDA
    very-low-density lipoprotein particle remodeling GO:0034372 IBA
    very-low-density lipoprotein particle remodeling GO:0034372 IDA
    low-density lipoprotein particle remodeling GO:0034374 IBA
    low-density lipoprotein particle remodeling GO:0034374 IDA
    high-density lipoprotein particle remodeling GO:0034375 IBA
    high-density lipoprotein particle remodeling GO:0034375 IDA
    high-density lipoprotein particle remodeling GO:0034375 IMP
    cholesterol homeostasis GO:0042632 IBA
    cholesterol homeostasis GO:0042632 IMP
    reverse cholesterol transport GO:0043691 IC
    phosphatidylcholine metabolic process GO:0046470 IBA
    phosphatidylcholine metabolic process GO:0046470 IDA
    lipid homeostasis GO:0055088 IDA
    phospholipid homeostasis GO:0055091 IBA
    phospholipid homeostasis GO:0055091 IDA
    triglyceride homeostasis GO:0070328 IBA
    triglyceride homeostasis GO:0070328 IDA
    positive regulation of phospholipid transport GO:2001140 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    vesicle GO:0031982 IDA
    high-density lipoprotein particle GO:0034364 IBA
    high-density lipoprotein particle GO:0034364 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CETP in sEVs
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CETP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKACG  
Two-hybrid Homo sapiens
2 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml



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