Gene description for CETP
Gene name cholesteryl ester transfer protein, plasma
Gene symbol CETP
Other names/aliases BPIFF
HDLCQ10
Species Homo sapiens
 Database cross references - CETP
ExoCarta ExoCarta_1071
Vesiclepedia VP_1071
Entrez Gene 1071
HGNC 1869
MIM 118470
UniProt P11597  
 CETP identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Urine 19056867    
 Gene ontology annotations for CETP
Molecular Function
    triglyceride binding GO:0017129 IDA
    lipid binding GO:0008289 IDA
    lipid transporter activity GO:0005319 IDA
    phosphatidylcholine binding GO:0031210 IDA
    cholesterol binding GO:0015485 IDA
    phospholipid transporter activity GO:0005548 IDA
    cholesterol transporter activity GO:0017127 IDA
Biological Process
    reverse cholesterol transport GO:0043691 IC
    high-density lipoprotein particle remodeling GO:0034375 IMP
    triglyceride metabolic process GO:0006641 IDA
    very-low-density lipoprotein particle remodeling GO:0034372 IDA
    cholesterol homeostasis GO:0042632 IMP
    lipoprotein metabolic process GO:0042157 TAS
    small molecule metabolic process GO:0044281 TAS
    lipid transport GO:0006869 IDA
    regulation of cholesterol efflux GO:0010874 IMP
    triglyceride homeostasis GO:0070328 IDA
    phospholipid homeostasis GO:0055091 IDA
    triglyceride transport GO:0034197 IDA
    phospholipid transport GO:0015914 IDA
    low-density lipoprotein particle remodeling GO:0034374 IDA
    lipid homeostasis GO:0055088 IDA
    negative regulation of macrophage derived foam cell differentiation GO:0010745 IC
    receptor-mediated endocytosis GO:0006898 TAS
    cholesterol transport GO:0030301 IDA
    cholesterol metabolic process GO:0008203 IMP
    phosphatidylcholine metabolic process GO:0046470 IDA
Subcellular Localization
    high-density lipoprotein particle GO:0034364 IDA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    vesicle GO:0031982 IDA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CETP in exosomes
1
Experiment ID 231
MISEV standards
✘ EV Biophysical techniques
✔
Alix|CD63|CD9
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CETP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APOA1 335
Affinity Capture-MS Homo sapiens
2 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CETP is involved
PathwayEvidenceSource
HDL-mediated lipid transport TAS Reactome
LDL-mediated lipid transport TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here