Gene description for AGT
Gene name	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene symbol	AGT
Other names/aliases	ANHU SERPINA8
Species	Homo sapiens
Database cross references - AGT
ExoCarta	ExoCarta_183
Entrez Gene	183
HGNC	333
MIM	106150
UniProt	P01019
AGT identified in exosomes derived from the following tissue/cell type
Plasma	19028452
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for AGT

Molecular Function     superoxide-generating NADPH oxidase activator activity GO:0016176 TAS     type 2 angiotensin receptor binding GO:0031703 IPI     hormone activity GO:0005179 ISS     protein binding GO:0005515 IPI     serine-type endopeptidase inhibitor activity GO:0004867 TAS     sodium channel regulator activity GO:0017080 IMP     type 1 angiotensin receptor binding GO:0031702 IPI     growth factor activity GO:0008083 TAS Biological Process     response to salt stress GO:0009651 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     positive regulation of NAD(P)H oxidase activity GO:0033864 TAS     response to cold GO:0009409 IEA     positive regulation of fatty acid biosynthetic process GO:0045723 IEA     ovarian follicle rupture GO:0001543 IEA     peristalsis GO:0030432 IEA     regulation of blood pressure GO:0008217 IGI     positive regulation of superoxide anion generation GO:0032930 IEA     positive regulation of cholesterol esterification GO:0010873 IDA     smooth muscle cell differentiation GO:0051145 IEA     blood vessel remodeling GO:0001974 TAS     angiotensin-mediated drinking behavior GO:0003051 IEA     cellular sodium ion homeostasis GO:0006883 IEA     positive regulation of vasodilation GO:0045909 IEA     G-protein coupled receptor signaling pathway GO:0007186 IDA     positive regulation of membrane hyperpolarization GO:1902632 IMP     positive regulation of gap junction assembly GO:1903598 IGI     cell-cell signaling GO:0007267 TAS     cellular lipid metabolic process GO:0044255 TAS     angiotensin maturation GO:0002003 TAS     renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure GO:0001999 IEA     positive regulation of cardiac muscle hypertrophy GO:0010613 ISS     positive regulation of multicellular organism growth GO:0040018 IEA     positive regulation of cytokine production GO:0001819 TAS     positive regulation of endothelial cell migration GO:0010595 IDA     cell growth involved in cardiac muscle cell development GO:0061049 IEA     astrocyte activation GO:0048143 IEA     negative regulation of sodium ion transmembrane transporter activity GO:2000650 TAS     activation of NF-kappaB-inducing kinase activity GO:0007250 IEA     positive regulation of activation of JAK2 kinase activity GO:0010535 IMP     small molecule metabolic process GO:0044281 TAS     positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA     positive regulation of organ growth GO:0046622 IEA     regulation of vasoconstriction GO:0019229 NAS     vasodilation GO:0042311 IEA     female pregnancy GO:0007565 IEA     positive regulation of extracellular matrix constituent secretion GO:0003331 IEA     cytokine secretion GO:0050663 IEA     regulation of norepinephrine secretion GO:0014061 IEA     response to muscle activity involved in regulation of muscle adaptation GO:0014873 ISS     regulation of cell growth GO:0001558 NAS     activation of phospholipase C activity GO:0007202 IEA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IDA     regulation of calcium ion transport GO:0051924 IEA     positive regulation of macrophage derived foam cell differentiation GO:0010744 IC     regulation of cell proliferation GO:0042127 NAS     stress-activated MAPK cascade GO:0051403 IEA     aging GO:0007568 IEA     extracellular matrix organization GO:0030198 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     catenin import into nucleus GO:0035411 IEA     regulation of renal output by angiotensin GO:0002019 NAS     artery smooth muscle contraction GO:0014824 IEA     negative regulation of endopeptidase activity GO:0010951 IBA     phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 NAS     negative regulation of angiogenesis GO:0016525 IEA     positive regulation of reactive oxygen species metabolic process GO:2000379 TAS     positive regulation of MAPK cascade GO:0043410 IEA     excretion GO:0007588 IEA     cellular protein metabolic process GO:0044267 TAS     negative regulation of cell proliferation GO:0008285 IEA     kidney development GO:0001822 IMP     renal system process GO:0003014 IDA     cellular response to mechanical stimulus GO:0071260 IEA     fibroblast proliferation GO:0048144 IEA     ERK1 and ERK2 cascade GO:0070371 IEA     positive regulation of protein kinase C activity GO:1900020 IEA     establishment of blood-nerve barrier GO:0008065 IEA     positive regulation of cellular protein metabolic process GO:0032270 IDA     nitric oxide mediated signal transduction GO:0007263 TAS     negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 IDA     regulation of transmission of nerve impulse GO:0051969 IEA     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IDA     positive regulation of protein tyrosine kinase activity GO:0061098 IMP     positive regulation of renal sodium excretion GO:0035815 IEA     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     regulation of extracellular matrix assembly GO:1901201 IGI     regulation of blood vessel size by renin-angiotensin GO:0002034 TAS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IDA     positive regulation of transcription, DNA-templated GO:0045893 IDA     blood vessel development GO:0001568 IEA     cell-matrix adhesion GO:0007160 IEA     negative regulation of tissue remodeling GO:0034104 IEA     positive regulation of inflammatory response GO:0050729 TAS     negative regulation of cell growth GO:0030308 IEA     low-density lipoprotein particle remodeling GO:0034374 NAS     branching involved in ureteric bud morphogenesis GO:0001658 IEA     smooth muscle cell proliferation GO:0048659 IEA     regulation of blood volume by renin-angiotensin GO:0002016 NAS     angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001998 IEA     regulation of cardiac conduction GO:1903779 IGI     renin-angiotensin regulation of aldosterone production GO:0002018 NAS     regulation of long-term neuronal synaptic plasticity GO:0048169 IEA     regulation of renal sodium excretion GO:0035813 NAS     positive regulation of fibroblast proliferation GO:0048146 ISS     uterine smooth muscle contraction GO:0070471 IEA     G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 TAS Subcellular Localization     extracellular space GO:0005615 ISS     extracellular exosome GO:0070062 IDA     extracellular region GO:0005576 TAS     cytoplasm GO:0005737 IEA     blood microparticle GO:0072562 IDA