Gene description for HAS1
Gene name hyaluronan synthase 1
Gene symbol HAS1
Other names/aliases HAS
Species Homo sapiens
 Database cross references - HAS1
ExoCarta ExoCarta_3036
Entrez Gene 3036
HGNC 4818
MIM 601463
UniProt Q92839  
 HAS1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for HAS1
Molecular Function
    hyaluronan synthase activity GO:0050501 ISS
Biological Process
    extracellular matrix assembly GO:0085029 ISS
    cell adhesion GO:0007155 TAS
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    hyaluronan biosynthetic process GO:0030213 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    carbohydrate metabolic process GO:0005975 TAS
    cellular response to platelet-derived growth factor stimulus GO:0036120 IDA
    hyaluronan metabolic process GO:0030212 TAS
    small molecule metabolic process GO:0044281 TAS
    negative regulation of fibroblast migration GO:0010764 IMP
    extracellular polysaccharide biosynthetic process GO:0045226 ISS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified HAS1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HAS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF6 3692
Affinity Capture-MS Homo sapiens
2 VHL  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HAS1 is involved
PathwayEvidenceSource
Hyaluronan biosynthesis and export TAS Reactome





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