Gene description for ZDHHC3
Gene name zinc finger, DHHC-type containing 3
Gene symbol ZDHHC3
Other names/aliases DHHC-3
GODZ
ZNF373
Species Homo sapiens
 Database cross references - ZDHHC3
ExoCarta ExoCarta_51304
Vesiclepedia VP_51304
Entrez Gene 51304
HGNC 18470
UniProt Q9NYG2  
 ZDHHC3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ZDHHC3
Molecular Function
    palmitoyltransferase activity GO:0016409 IDA
    protein-cysteine S-myristoyltransferase activity GO:0019705 IEA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IBA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISS
    protein-cysteine S-palmitoyltransferase activity GO:0019706 TAS
    protein homodimerization activity GO:0042803 ISS
    protein-cysteine S-stearoyltransferase activity GO:0140439 IEA
Biological Process
    protein targeting to membrane GO:0006612 IBA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IBA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IMP
    peptidyl-L-cysteine S-palmitoylation GO:0018230 ISS
    protein palmitoylation GO:0018345 IDA
    protein palmitoylation GO:0018345 IMP
    positive regulation of synaptic transmission, GABAergic GO:0032230 ISS
    positive regulation of toll-like receptor 9 signaling pathway GO:0034165 IDA
    TRAIL-activated apoptotic signaling pathway GO:0036462 IMP
    lipoprotein localization to membrane GO:0044873 IMP
    protein localization to membrane GO:0072657 TAS
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 IDA
    protein localization to plasma membrane GO:0072659 IMP
    positive regulation of receptor localization to synapse GO:1902685 ISS
    protein localization to photoreceptor outer segment GO:1903546 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum GO:0005783 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified ZDHHC3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZDHHC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPR35  
Two-hybrid Homo sapiens
2 SMAD1 4086
Two-hybrid Homo sapiens
3 CD27  
Affinity Capture-MS Homo sapiens
4 TMED10 10972
Affinity Capture-MS Homo sapiens
5 COPB2 9276
Affinity Capture-MS Homo sapiens
6 EWSR1 2130
Two-hybrid Homo sapiens
7 UBQLN4 56893
Two-hybrid Homo sapiens
8 C1orf210  
Affinity Capture-MS Homo sapiens
9 SLC34A2 10568
Affinity Capture-MS Homo sapiens
10 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
11 SCAP  
Affinity Capture-MS Homo sapiens
12 NEDD4L 23327
Biochemical Activity Homo sapiens
13 GORASP2 26003
Affinity Capture-MS Homo sapiens
14 HLA-C 3107
Affinity Capture-MS Homo sapiens
15 HCST  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here