Gene description for STXBP6
Gene name syntaxin binding protein 6 (amisyn)
Gene symbol STXBP6
Other names/aliases HSPC156
amisyn
Species Homo sapiens
 Database cross references - STXBP6
ExoCarta ExoCarta_29091
Entrez Gene 29091
HGNC 19666
MIM 607958
UniProt Q8NFX7  
 STXBP6 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for STXBP6
Molecular Function
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA
    GTP-Rho binding GO:0017049 IBA
Biological Process
    exocyst localization GO:0051601 IBA
    Golgi to plasma membrane transport GO:0006893 IBA
    negative regulation of exocytosis GO:0045920 TAS
    exocytosis GO:0006887 IBA
    regulation of SNARE complex assembly GO:0035542 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    exocyst GO:0000145 IBA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified STXBP6 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STXBP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNAP25 6616
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 STX1A 6804
Invitro Homo sapiens
Invivo Homo sapiens
3 STX4 6810
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STXBP6 is involved
No pathways found





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