Gene description for USP31
Gene name ubiquitin specific peptidase 31
Gene symbol USP31
Other names/aliases -
Species Homo sapiens
 Database cross references - USP31
ExoCarta ExoCarta_57478
Entrez Gene 57478
HGNC 20060
UniProt Q70CQ4  
 USP31 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for USP31
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IDA
    cysteine-type endopeptidase activity GO:0004197 IBA
Biological Process
    protein deubiquitination GO:0016579 IDA
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified USP31 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for USP31
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which USP31 is involved
No pathways found





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