Gene description for PCDH19
Gene name protocadherin 19
Gene symbol PCDH19
Other names/aliases EFMR
EIEE9
Species Homo sapiens
 Database cross references - PCDH19
ExoCarta ExoCarta_57526
Vesiclepedia VP_57526
Entrez Gene 57526
HGNC 14270
MIM 300460
UniProt Q8TAB3  
 PCDH19 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PCDH19
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified PCDH19 in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PCDH19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPHA2 1969
Proximity Label-MS Homo sapiens
2 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TRIM66  
Affinity Capture-MS Homo sapiens
4 PCDH12 51294
Affinity Capture-MS Homo sapiens
5 RYK 6259
Affinity Capture-MS Homo sapiens
6 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SPSB4  
Affinity Capture-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 LPAR1 1902
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCDH19 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the nephric duct IEA Reactome
Kidney development IEA Reactome





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