Gene description for PPM1L
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1L
Gene symbol PPM1L
Other names/aliases PP2C-epsilon
PP2CE
PPM1-LIKE
Species Homo sapiens
 Database cross references - PPM1L
ExoCarta ExoCarta_151742
Entrez Gene 151742
HGNC 16381
MIM 611931
UniProt Q5SGD2  
 PPM1L identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for PPM1L
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    sphingolipid metabolic process GO:0006665 TAS
    sphingolipid biosynthetic process GO:0030148 TAS
    protein dephosphorylation GO:0006470 IEA
    transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IEA
    small molecule metabolic process GO:0044281 TAS
    MAPK cascade GO:0000165 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified PPM1L in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for PPM1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPM1L is involved
PathwayEvidenceSource
Sphingolipid de novo biosynthesis TAS Reactome





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