Gene description for INPP4A
Gene name inositol polyphosphate-4-phosphatase, type I, 107kDa
Gene symbol INPP4A
Other names/aliases INPP4
TVAS1
Species Homo sapiens
 Database cross references - INPP4A
ExoCarta ExoCarta_3631
Entrez Gene 3631
HGNC 6074
MIM 600916
UniProt Q96PE3  
 INPP4A identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for INPP4A
Molecular Function
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity GO:0034597 IEA
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity GO:0016316 IEA
Biological Process
    dephosphorylation GO:0016311 IEA
    inositol phosphate metabolic process GO:0043647 TAS
    small molecule metabolic process GO:0044281 TAS
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA
    signal transduction GO:0007165 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified INPP4A in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for INPP4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAPN1 823
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
2 PIK3R1 5295
Invivo Homo sapiens
3 SMAD1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here