Gene description for ADGRG2
Gene name adhesion G protein-coupled receptor G2
Gene symbol ADGRG2
Other names/aliases EDDM6
GPR64
HE6
TM7LN2
Species Homo sapiens
 Database cross references - ADGRG2
ExoCarta ExoCarta_10149
Entrez Gene 10149
HGNC 4516
MIM 300572
UniProt Q8IZP9  
 ADGRG2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Saliva 19199708    
 Gene ontology annotations for ADGRG2
Molecular Function
    G-protein coupled receptor activity GO:0004930 IEA
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    spermatogenesis GO:0007283 TAS
Subcellular Localization
    cell surface GO:0009986 IDA
    integral component of plasma membrane GO:0005887 TAS
    apical plasma membrane GO:0016324 ISS
    integral component of membrane GO:0016021 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified ADGRG2 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for ADGRG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADGRG2 is involved
No pathways found





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