Gene description for Tbcb
Gene name tubulin folding cofactor B
Gene symbol Tbcb
Other names/aliases 2410007D12Rik
AU041393
CG22
CKAPI
Ckap1
Species Mus musculus
 Database cross references - Tbcb
ExoCarta ExoCarta_66411
Vesiclepedia VP_66411
Entrez Gene 66411
UniProt Q9D1E6  
 Tbcb identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tbcb
Molecular Function
    protein binding GO:0005515 IPI
    alpha-tubulin binding GO:0043014 IEA
    microtubule plus-end binding GO:0051010 IBA
Biological Process
    tubulin complex assembly GO:0007021 IEA
    post-chaperonin tubulin folding pathway GO:0007023 IEA
    nervous system development GO:0007399 IEA
    cell differentiation GO:0030154 IEA
    cytoplasmic microtubule organization GO:0031122 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    microtubule GO:0005874 IEA
    cell cortex GO:0005938 IBA
    microtubule plus-end GO:0035371 IBA
 Experiment description of studies that identified Tbcb in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tbcb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ogfod1  
Co-fractionation Mus musculus
2 Tuba4a 22145
Co-fractionation Mus musculus
3 Eif5 217869
Co-fractionation Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Ptma  
Co-fractionation Mus musculus
6 Gan  
Co-fractionation Mus musculus
7 Isoc1 66307
Co-fractionation Mus musculus
8 Twf2  
Co-fractionation Mus musculus
9 Ubfd1  
Co-fractionation Mus musculus
10 Stk24 223255
Co-fractionation Mus musculus
11 Scpep1  
Co-fractionation Mus musculus
12 Ckb 12709
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Tbcb is involved
No pathways found





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