Gene description for Ppp2r4
Gene name protein phosphatase 2A activator, regulatory subunit B
Gene symbol Ppp2r4
Other names/aliases 2610042B21Rik
C77440
N28142
PR53
Species Mus musculus
 Database cross references - Ppp2r4
ExoCarta ExoCarta_110854
Vesiclepedia VP_110854
Entrez Gene 110854
UniProt P58389  
 Ppp2r4 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppp2r4
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    ATPase activity GO:0016887 ISO
    protein phosphatase type 2A regulator activity GO:0008601 ISO
    isomerase activity GO:0016853 IEA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    ATP binding GO:0005524 ISO
    nucleotide binding GO:0000166 IEA
    protein tyrosine phosphatase activator activity GO:0008160 ISO
    phosphatase activator activity GO:0019211 IEA
    receptor binding GO:0005102 ISO
    protein phosphatase 2A binding GO:0051721 ISO
Biological Process
    negative regulation of protein dephosphorylation GO:0035308 ISO
    positive regulation of protein dephosphorylation GO:0035307 ISO
    positive regulation of phosphoprotein phosphatase activity GO:0032516 ISO
    negative regulation of phosphoprotein phosphatase activity GO:0032515 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    mitotic spindle organization in nucleus GO:0030472 IBA
    regulation of protein phosphatase type 2A activity GO:0034047 ISO
    regulation of phosphoprotein phosphatase activity GO:0043666 ISO
    metabolic process GO:0008152 ISO
    protein peptidyl-prolyl isomerization GO:0000413 IBA
    positive regulation of catalytic activity GO:0043085 IBA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 ISO
    nucleoplasm GO:0005654 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    calcium channel complex GO:0034704 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Ppp2r4 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppp2r4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ppp2r4 is involved
No pathways found





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