Gene description for POP4
Gene name processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
Gene symbol POP4
Other names/aliases RPP29
Species Homo sapiens
 Database cross references - POP4
ExoCarta ExoCarta_10775
Vesiclepedia VP_10775
Entrez Gene 10775
HGNC 30081
MIM 606114
UniProt O95707  
 POP4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for POP4
Molecular Function
    ribonuclease P activity GO:0004526 IDA
    protein binding GO:0005515 IPI
    ribonuclease P RNA binding GO:0033204 IBA
    ribonuclease P RNA binding GO:0033204 IDA
Biological Process
    tRNA 5'-leader removal GO:0001682 IDA
    rRNA processing GO:0006364 IBA
Subcellular Localization
    ribonuclease MRP complex GO:0000172 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    ribonuclease P complex GO:0030677 IBA
    multimeric ribonuclease P complex GO:0030681 IDA
 Experiment description of studies that identified POP4 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for POP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 TFR2 7036
Affinity Capture-MS Homo sapiens
3 FTL 2512
Affinity Capture-MS Homo sapiens
4 HFE  
Affinity Capture-MS Homo sapiens
5 RAMP3  
Affinity Capture-MS Homo sapiens
6 OSTF1 26578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 POP7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SNX27 81609
Affinity Capture-MS Homo sapiens
9 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 AKT1 207
Biochemical Activity Homo sapiens
12 RPP30 10556
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
13 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NPM3 10360
Affinity Capture-MS Homo sapiens
16 POP1 10940
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
17 RPP25L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RMRP 6023
Affinity Capture-Western Homo sapiens
19 VTN 7448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 DNAJA2 10294
Affinity Capture-MS Homo sapiens
21 POP5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 C18orf21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RPP14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 POP4 10775
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
27 RPL10 6134
Affinity Capture-MS Homo sapiens
28 SSB 6741
Affinity Capture-MS Homo sapiens
29 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PCDHA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 DRG1 4733
Affinity Capture-MS Homo sapiens
32 Ppp2ca 19052
Affinity Capture-MS Mus musculus
33 RBM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 VSIG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 USP36  
Affinity Capture-MS Homo sapiens
36 PRKCSH 5589
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 RBM4 5936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SPOCK2  
Affinity Capture-MS Homo sapiens
39 S100A4 6275
Affinity Capture-MS Homo sapiens
40 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RPP25  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
42 RPP40 10799
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GPR182  
Affinity Capture-MS Homo sapiens
44 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CBX6  
Affinity Capture-MS Homo sapiens
46 RPP21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PRPF4 9128
Affinity Capture-MS Homo sapiens
48 CHMP2A 27243
Affinity Capture-MS Homo sapiens
49 DDRGK1 65992
Affinity Capture-MS Homo sapiens
50 ANOS1 3730
Affinity Capture-MS Homo sapiens
51 PIPSL 266971
Affinity Capture-MS Homo sapiens
52 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PDCD11 22984
Affinity Capture-MS Homo sapiens
54 HIBCH 26275
Affinity Capture-MS Homo sapiens
55 CBWD1 55871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ZNF467  
Affinity Capture-MS Homo sapiens
57 RPP38 10557
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
58 TRAK1 22906
Affinity Capture-MS Homo sapiens
59 AMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PPP1R15A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 C3orf17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which POP4 is involved
PathwayEvidenceSource
Metabolism of RNA TAS Reactome
tRNA processing TAS Reactome
tRNA processing in the nucleus TAS Reactome





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