Gene description for POP4
Gene name processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
Gene symbol POP4
Other names/aliases RPP29
Species Homo sapiens
 Database cross references - POP4
ExoCarta ExoCarta_10775
Entrez Gene 10775
HGNC 30081
MIM 606114
UniProt O95707  
 POP4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for POP4
Molecular Function
    ribonuclease P activity GO:0004526 IEA
    protein binding GO:0005515 IPI
    ribonuclease MRP activity GO:0000171 IBA
    RNA binding GO:0003723 TAS
    ribonuclease P RNA binding GO:0033204 IBA
Biological Process
    RNA phosphodiester bond hydrolysis GO:0090501 TAS
    tRNA processing GO:0008033 IEA
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 TAS
    rRNA processing GO:0006364 IEA
    mRNA cleavage GO:0006379 IEA
Subcellular Localization
    ribonuclease P complex GO:0030677 IBA
    nucleolar ribonuclease P complex GO:0005655 IEA
    ribonuclease MRP complex GO:0000172 IEA
 Experiment description of studies that identified POP4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for POP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POP5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 RMRP 6023
Affinity Capture-Western Homo sapiens
3 POP4 10775
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 RPP25  
Reconstituted Complex Homo sapiens
5 RPP30 10556
Two-hybrid Homo sapiens
6 RPP38  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 POP1 10940
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which POP4 is involved
No pathways found





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