Gene description for Hspa1l
Gene name heat shock protein 1-like
Gene symbol Hspa1l
Other names/aliases Hsc70t
Msh5
Species Mus musculus
 Database cross references - Hspa1l
ExoCarta ExoCarta_15482
Entrez Gene 15482
UniProt P16627  
 Hspa1l identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Hspa1l
Molecular Function
    ATP binding GO:0005524 IEA
    unfolded protein binding GO:0051082 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    nucleotide binding GO:0000166 IEA
Biological Process
    binding of sperm to zona pellucida GO:0007339 IDA
    multicellular organismal development GO:0007275 IEA
    cell differentiation GO:0030154 IEA
    protein refolding GO:0042026 ISO
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    spermatogenesis GO:0007283 IEA
Subcellular Localization
    blood microparticle GO:0072562 ISO
    COP9 signalosome GO:0008180 ISO
    zona pellucida receptor complex GO:0002199 IDA
    cell body GO:0044297 IDA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Hspa1l in exosomes
1
Experiment ID 33
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hspa1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hspa1l is involved
PathwayEvidenceSource
HSF1-dependent transactivation IEA Reactome





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