Gene description for Hspa1l
Gene name heat shock protein 1-like
Gene symbol Hspa1l
Other names/aliases Hsc70t
Msh5
Species Mus musculus
 Database cross references - Hspa1l
ExoCarta ExoCarta_15482
Entrez Gene 15482
UniProt P16627  
 Hspa1l identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Hspa1l
Molecular Function
    ATP binding GO:0005524 IEA
    unfolded protein binding GO:0051082 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    nucleotide binding GO:0000166 IEA
Biological Process
    binding of sperm to zona pellucida GO:0007339 IDA
    multicellular organismal development GO:0007275 IEA
    cell differentiation GO:0030154 IEA
    protein refolding GO:0042026 ISO
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    spermatogenesis GO:0007283 IEA
Subcellular Localization
    blood microparticle GO:0072562 ISO
    COP9 signalosome GO:0008180 ISO
    zona pellucida receptor complex GO:0002199 IDA
    cell body GO:0044297 IDA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Hspa1l in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hspa1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hspa1l is involved
PathwayEvidenceSource
HSF1-dependent transactivation IEA Reactome





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