Gene description for Eif2s1
Gene name eukaryotic translation initiation factor 2, subunit 1 alpha
Gene symbol Eif2s1
Other names/aliases 0910001O23Rik
Species Mus musculus
 Database cross references - Eif2s1
ExoCarta ExoCarta_13665
Entrez Gene 13665
UniProt Q6ZWX6  
 Eif2s1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Eif2s1
Molecular Function
    ribosome binding GO:0043022 ISO
    RNA binding GO:0003723 IEA
    translation initiation factor activity GO:0003743 ISO
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 ISO
    nucleic acid binding GO:0003676 IEA
Biological Process
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO
    translation GO:0006412 ISO
    protein autophosphorylation GO:0046777 IDA
    translational initiation GO:0006413 ISO
    positive regulation of defense response to virus by host GO:0002230 ISO
    regulation of translation GO:0006417 IEA
    regulation of translational initiation in response to stress GO:0043558 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    eukaryotic translation initiation factor 2 complex GO:0005850 IBA
    cytoplasmic stress granule GO:0010494 IDA
    cytoplasm GO:0005737 IDA
    multi-eIF complex GO:0043614 IBA
    nucleus GO:0005634 IDA
    ribosome GO:0005840 IBA
    membrane GO:0016020 ISO
    eukaryotic translation initiation factor 2B complex GO:0005851 ISO
    eukaryotic 48S preinitiation complex GO:0033290 IBA
 Experiment description of studies that identified Eif2s1 in exosomes
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Eif2s1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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