Gene description for Srsf6
Gene name serine/arginine-rich splicing factor 6
Gene symbol Srsf6
Other names/aliases 1210001E11Rik
AI314910
AW146126
Sfrs6
Species Mus musculus
 Database cross references - Srsf6
ExoCarta ExoCarta_67996
Vesiclepedia VP_67996
Entrez Gene 67996
UniProt Q3TWW8  
 Srsf6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Srsf6
Molecular Function
    RNA binding GO:0003723 ISO
    RNA binding GO:0003723 ISS
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    pre-mRNA binding GO:0036002 ISO
    pre-mRNA binding GO:0036002 ISS
Biological Process
    alternative mRNA splicing, via spliceosome GO:0000380 ISO
    alternative mRNA splicing, via spliceosome GO:0000380 ISS
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISO
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISO
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISS
    mRNA splice site recognition GO:0006376 ISO
    mRNA splice site recognition GO:0006376 ISS
    negative regulation of gene expression GO:0010629 ISO
    regulation of keratinocyte proliferation GO:0010837 ISO
    regulation of keratinocyte proliferation GO:0010837 ISS
    response to insulin GO:0032868 IEA
    negative regulation of keratinocyte differentiation GO:0045617 ISO
    negative regulation of keratinocyte differentiation GO:0045617 ISS
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IEA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 ISO
    positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 ISO
    regulation of wound healing GO:0061041 ISO
    regulation of wound healing GO:0061041 ISS
    negative regulation of type B pancreatic cell apoptotic process GO:2000675 IEA
    negative regulation of type B pancreatic cell apoptotic process GO:2000675 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    nuclear speck GO:0016607 ISO
    nuclear speck GO:0016607 ISS
 Experiment description of studies that identified Srsf6 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Srsf6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SRSF4 6429
Two-hybrid Homo sapiens
2 NXF1 10482
Two-hybrid Homo sapiens
3 PNO1 56902
Two-hybrid Homo sapiens
4 Eif2s1 13665
Two-hybrid Mus musculus
5 Mapt  
Affinity Capture-MS Mus musculus
6 SF3B4 10262
Two-hybrid Homo sapiens
7 LUC7L 55692
Two-hybrid Homo sapiens
8 Cpsf6  
Two-hybrid Mus musculus
9 Fancd2  
Affinity Capture-MS Mus musculus
10 LPAR1 1902
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Srsf6 is involved
No pathways found





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